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Chaperone mediated autophagy contributes to the newly synthesized histones H3 and H4 quality control
(2022)
Although there are several pathways to ensure that proteins are folded properly in the cell, little is known about the molecular mechanisms regulating histone folding and proteostasis. In this work, we identified that ...
Chaperone mediated autophagy contributes to the newly synthesized histones H3 and H4 quality control
(2022-02-28)
Although there are several pathways to ensure that proteins are folded properly in the cell, little is known about the molecular mechanisms regulating histone folding and proteostasis. In this work, we identified that ...
Use of synthetic peptides for identifying biotinylation sites in human histones
(Humana Press, 2008)
Posttranslational modifications of histones play an important role in the regulation of chromatin structure and, hence, gene regulation. Recently, we have identified a novel modification of histones: binding of the vitamin ...
JMJD1B, a novel player in histone H3 and H4 processing to ensure genome stability
(2020-02-18)
Background: Maintaining a proper supply of soluble histones throughout the cell cycle is important to ensure chromatin and genome stability. Following their synthesis, histones undergo a series of maturation steps to prepare ...
Design and synthesis of hybrid compounds as epigenetic modifiers
(2021-12-01)
Epigenetic modifiers acting through polypharmacology mechanisms are promising compounds with which to treat several infectious diseases. Histone deacetylase (HDAC) enzymes, mainly class I, and extra-terminal bromodomains ...
Synthesis and biological evaluation of novel thiazolyl-coumarin derivatives as potent histone deacetylase inhibitors with antifibrotic activity
(MDPI AG, 2019)
New histone deacetylases (HDAC) inhibitors with low toxicity to non-cancerous cells, are a prevalent issue at present because these enzymes are actively involved in fibrotic diseases. We designed and synthesized a novel ...
Discovery of phenylsulfonylfuroxan derivatives as gamma globin inducers by histone acetylation
(2018-06-25)
N-oxide derivatives 5(a-b), 8(a-b), and 11(a-c) were designed, synthesized and evaluated in vitro and in vivo as potential drugs that are able to ameliorate sickle cell disease (SCD) symptoms. All of the compounds demonstrated ...
Estudio de la degradación de la histona H3 citosólica mal plegada por el sistema ubiquitina-proteosoma
(Universidad de Chile, 2017)
Las histonas son proteínas pequeñas con una alta carga positiva, capaces de interactuar con el ADN y ayudar en su compactación. Antes de poder ejercer esta función estas proteínas son sintetizadas en el citoplasma celular, ...
Síntese de inibidores duais como agentes reversores de latencia para HIV
(Universidade Estadual Paulista (Unesp), 2021-12-17)
O vírus da imunodeficiência humana (HIV) é o causador da síndrome da imunodeficiência adquirida (SIDA ou AIDS em inglês). Embora altamente efetivo na redução da carga viral, o tratamento com a terapia antirretroviral (TARV) ...