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Synaptotagmin 1 oligomers clamp and regulate different modes of neurotransmitter release
(National Academy of Sciences, 2020-02)
Synaptotagmin 1 (Syt1) synchronizes neurotransmitter release to action potentials (APs) acting as the fast Ca2+ release sensor and as the inhibitor (clamp) of spontaneous and delayed asynchronous release. While the Syt1 ...
The Synaptotagmin-1 C2B Domain Is a Key Regulator in the Stabilization of the Fusion Pore
(American Chemical Society, 2020-11)
Fusion pores serve as an effective mechanism to connect intracellular organelles and release vesicle contents during exocytosis. A complex lipid rearrangement takes place as membranes approximate, bend, fuse, and establish ...
Increased expression of SNARE proteins and synaptotagmin IV in islets from pregnant rats and in vitro prolactin-treated neonatal islets
(Sociedad Biolgia ChileSantiagoChile, 2006)
Rearrangements under confinement lead to increased binding energy of Synaptotagmin-1 with anionic membranes in Mg2+ and Ca2+
(Elsevier Science, 2018-04)
Synaptotagmin-1 (Syt1) is the primary calcium sensor (Ca2+ ) that mediates neurotransmitter release at the synapse. The tandem C2 domains (C2A and C2B) of Syt1 exhibit functionally critical, Ca2+ -dependent interactions ...
Synaptotagmin oligomerization is essential for calcium control of regulated exocytosis
(National Academy of Sciences, 2018-08)
Regulated exocytosis, which underlies many intercellular signaling events, is a tightly controlled process often triggered by calcium ion(s) (Ca2+). Despite considerable insight into the central components involved, namely, ...
Synaptotagmin-1 overexpression under inflammatory conditions affects secretion in salivary glands from Sjögren's syndrome patients
(Academic Press, 2019)
Sjögren's syndrome (SS) is an autoimmune exocrinopathy associated with severe secretory alterations by disruption of the glandular architecture integrity, which is fundamental for a correct function and localization of the ...
Stimulation of MMP-1 and CCL2 by NAMPT in PDL cells
(2013-09-23)
Periodontitis is an inflammatory disease caused by pathogenic microorganisms and characterized by the destruction of the periodontium. Obese individuals have an increased risk of periodontitis, and elevated circulating ...
Stimulation of MMP-1 and CCL2 by NAMPT in PDL cells
(2013-09-23)
Periodontitis is an inflammatory disease caused by pathogenic microorganisms and characterized by the destruction of the periodontium. Obese individuals have an increased risk of periodontitis, and elevated circulating ...
Synaptotagmin-1 overexpression under inflammatory conditions affects secretion in salivary glands from Sjogren's syndrome patients
(Facultad de Odontología, 2019)
Sjogren's syndrome (SS) is an autoimmune exocrinopathy associated with severe secretory alterations by disruption of the glandular architecture integrity, which is fundamental for a correct function and localization of the ...