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Free radical production and antioxidant status in brain cortex non-synaptic mitochondria and synaptosomes at alcohol hangover onset
(Elsevier Science Inc, 2017-07)
Alcohol hangover (AH) is the pathophysiological state after a binge-like drinking. We have previously demonstrated that AH induced bioenergetics impairments in a total fresh mitochondrial fraction in brain cortex and ...
Synaptosome Bioenergetics and Calcium Handling: Aging Response
(Humana Press, 2018)
Synaptic function and the role of mitochondria inside nerve terminals can be studied by the isolation of an enriched fraction of synaptosomes, which consist in nerve ending particles that are formed during homogenization ...
Alcohol hangover effects on brain cortex non-synaptic mitochondria and synaptosomes bioenergetics
(Elsevier Science Inc, 2019-03)
Alcohol hangover (AH) has been associated with oxidative stress and mitochondrial dysfunction. We herein postulate that AH-induced mitochondrial alterations can be due to a different pattern of response in synaptosomes and ...
Phosphatidylinositol 4,5-bisphosphate induced flunitrazepam sensitive-GABAA receptor increase in synaptosomes from chick forebrain
(Springer/Plenum Publishers, 2007-06)
The flunitrazepam sensitive-GABAA receptor density was increased by cytochalasins C and D at 37°C suggesting that microfilament depolymerization induces exposure to the radioligand of a GABAA receptor in synaptosomes (Pharm ...
Nantenine and papaverine differentially modify synaptosomal membrane enzymes
(Urban & Fischer Verlag, 2000-07-01)
Papaverine (1-[(3,4-Dimethoxyphenyl) methyl]-6,7-dimethoxyisoquinoline) and nantenine (O-methyldomesticine) are chemically related isoquinoline alkaloids displaying similar dose-dependent sedative or convulsant effects, ...
GABAergic agonists modulate the glutamate release from frontal cortex synaptosomes of rats with experimental autoimmune encephalomyelitis
(Bentham Science, 2015-10)
Experimental autoimmune encephalomyelitis (EAE) is a model that mimics many of the clinical and pathological features of multiple sclerosis. We have previously found a significant reduction in the GABAergic regulation of ...
Phosphatidic acid and diacylglycerol generation is regulated by insulin in cerebral cortex synaptosomes from adult and aged rats
(Veterinary and Human Toxicology, 2005-07)
Insulin receptor associated with the cerebral cortex (CC) has been shown to be involved in brain cognitive functions. Furthermore, deterioration of insulin signaling has been associated with age-related brain degenera tion. ...
Brain cortex mitochondrial bioenergetics in synaptosomes and non-synaptic mitochondria during aging
(Springer/Plenum Publishers, 2016-01)
Alterations in mitochondrial bioenergetics have been associated with brain aging. In order to evaluate the susceptibility of brain cortex synaptosomes and non-synaptic mitochondria to aging-dependent dysfunction, male Swiss ...
Alcohol hangover induces nitric oxide metabolism changes by impairing NMDA receptor-PSD95-nNOS pathway
(Academic Press Inc Elsevier Science, 2021-09)
Alcohol hangover is defined as the combination of mental and physical symptoms experienced the day after a single episode of heavy drinking, starting when blood alcohol concentration approaches zero. We previously evidenced ...
Gabaergic agonists modulate the glutamate release from frontal cortex synaptosomes of rats with experimental autoimmune encephalomyelitis
(Bentham Science Publishers, 2015-04)
Experimental autoimmune encephalomyelitis (EAE) is an inflammatory demyelinating disease that mimics many of the clinical and pathological features of multiple sclerosis. We have previously described a significant diminution ...