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Modeling tumor evolutionary dynamics
(2013-02)
Analysis of somatic mutations in BRAF, CDKN2A/p16 and PI3KCA in patients with medullary thyroid carcinoma
(Spandidos Publ Ltd, 2016)
Medullary thyroid carcinoma (MTC), a neuroendocrine tumor originating from thyroid parafollicular cells, has been demonstrated to be associated with mutations in RET, HRAS, KRAS and NRAS. However, the role of other genes ...
Genomic instability at the 13q31 locus and somatic mtDNA mutation in the D-loop site correlate with tumor aggressiveness in sporadic brazilian breast cancer cases
(Faculdade de Medicina, Universidade de Sao Paulo, 2014)
Autonomous adenomas caused by somatic mutations of the thyroid-stimulating hormone receptor in children.
(2014)
In adults, autonomous adenomas of the thyroid causing hyperthyroidism are relatively common and are most often due to somatic mutations that increase the constitutive activity of the thyroid-stimulating hormone receptor ...
Somatic Mutations and Ancestry Markers in Hispanic Lung Cancer Patients
(Elsevier, 2017)
Background: This study examined lung cancer tumor samples from 163 Hispanic patients. Tumor-derived DNA was subjected to targeted-exome sequencing and ancestry analysis. Results: Among adenocarcinomas (n=120) in the Hispanic ...
Mutation and genomic amplification of the PIK3CA proto-oncogene in pituitary adenomas
(Associação Brasileira de Divulgação Científica, 2012)
The tumorigenesis of pituitary adenomas is poorly understood. Mutations of the PIK3CA proto-oncogene, which encodes the p110-α catalytic subunit of PI3K, have been reported in various types of human cancers regarding ...