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Identification of inhibitors to Trypanosoma cruzi Sirtuins based on compounds developed to human enzymes
(MDPI, 2020)
Chagas disease is an illness caused by the protozoan parasite Trypanosoma cruzi, a↵ecting more than 7 million people in the world. Benznidazole and nifurtimox are the only drugs available for treatment and in addition to ...
Identification of Inhibitors to Trypanosoma cruzi Sirtuins Based on Compounds Developed to Human Enzymes
(Cognizant Communication Corporation, 2020)
Potential modulation of sirtuins by oxidative stress
(Hindawi Publishing Corporation, 2016)
Sirtuins are a conserved family of NAD-dependent protein deacylases. Initially proposed as histone deacetylases, it is now known that they act on a variety of proteins including transcription factors and metabolic enzymes, ...
Schistosoma mansoni Sirtuins: Characterization and Potential as Chemotherapeutic Targets
(Public Library of Science, 2018)
Sirtuins and the circadian clock interplay in cardioprotection: focus on sirtuin 1
(Springer Nature, 2022)
SIRT3 deacetylase: the Jekyll and Hyde sirtuin
(Embo Press, 2011-08)
Post‐translational modifications have crucial roles in regulating the functions of many eukaryotic proteins. Among them, lysine acetylation has been traditionally studied in the context of nuclear histone modifications, ...
Chemical constituents of Anacardium occidentale as inhibitors of Trypanosoma cruzi Sirtuins
(MDPI, 2019)
Benznidazole and nifurtimox, the only drugs available for the treatment of Chagas disease, have limited efficacy and have been associated with severe adverse side effects. Thus, there is an urgent need to find new biotargets ...