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Mostrando ítems 1-10 de 20
Probing infectious disease by single-cell RNA sequencing: progresses and perspectives
The increasing application of single-cell RNA sequencing (scRNA-seq) technology in life
science and biomedical research has significantly increased our understanding of the cellular
heterogeneities in immunology, oncology ...
Interpretable Deep Embeddings for Single-cell RNA-seq Clustering Analysis via Gene Attention
(Universidad de los AndesIngeniería de Sistemas y ComputaciónFacultad de IngenieríaDepartamento de Ingeniería Sistemas y Computación, 2022-12-16)
This work presents a ZINB model-based denoising autoencoder that offers interpretable deep embeddings through a gene attention mechanism for single-cell RNA-seq clustering. Our method performs a dimensionality reduction ...
Combining single-cell RNA-sequencing with a molecular atlas unveils new markers for Caenorhabditis elegans neuron classes
(Oxford University Press, 2020-06)
Single-cell RNA-sequencing (scRNA-seq) of the Caenorhabditis elegans nervous system offers the unique opportunity to obtain a partial expression profile for each neuron within a known connectome. Building on recent scRNA-seq ...
An Integrative Single-cell Transcriptomic Atlas of the Post-natal Mouse Mammary Gland Allows Discovery of New Developmental Trajectories in the Luminal Compartment
(Springer/Plenum Publishers, 2021-11)
The mammary gland is a highly dynamic organ which undergoes periods of expansion, differentiation and cell death in each reproductive cycle. Partly because of the dynamic nature of the gland, mammary epithelial cells (MECs) ...
Aspectos Celulares e Moleculares do Desenvolvimento dos Linfócitos T no Timo Humano
(Florianópolis, SC, 2021)
Effective treatment of SARS-CoV-2-infected rhesus macaques by attenuating inflammation
The COVID-19 pandemic caused by the SARS-CoV-2 virus has
caused a significant public health crisis worldwide. Recent studies
show that excessive inflammatory response is critical for SARSCoV-2 pathogenesis and COVID-19 ...
De Novo Assembly And Transcriptome Analysis Of Contrasting Sugarcane Varieties
(Public Library of Science, 2014)
Development of a non-viral delivery nanoplatform for genomic therapy based on iron oxide nanoparticles and recombinant Cas9 for potential use in genetic heterozygous orphan diseases
(Universidad de los AndesMaestría en Ingeniería BiomédicaFacultad de IngenieríaDepartamento de Ingeniería Biomédica, 2022-01-31)
Since it was first described, the CRISPR/Cas9 technology has opened new possibilities in the molecular biology fields. CRISPR/Cas9 has become one of the favorite tools for researchers from cell culture improvement to design ...