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Palbociclib-Induced Cellular Senescence Is Modulated by the mTOR Complex 1 and Autophagy
(Multidisciplinary Digital Publishing Institute (MDPI), 2024)
Mitofusins modulate the increase in mitochondrial length, bioenergetics and secretory phenotype in therapy-induced senescent melanoma cells
(Portland Press, 2019)
Cellular senescence is an endpoint of chemotherapy, and targeted therapies in melanoma and the senescence-associated secretory phenotype (SASP) can affect tumor
growth and microenvironment, influencing treatment outcomes. ...
A Mir-335/cox-2/pten Axis Regulates The Secretory Phenotype Of Senescent Cancer-associated Fibroblasts
(Impact Journals LlcAlbany, 2016)
Senescent CD4+CD28− T lymphocytes as a potential driver of Th17/Treg imbalance and alveolar bone resorption during periodontitis
(MDPI, 2022)
Senescent cells express a senescence-associated secretory phenotype (SASP) with a pro-inflammatory bias, which contributes to the chronicity of inflammation. During chronic inflammatory diseases, infiltrating CD4(+) T ...
Senescence Markers in Peripheral Blood Mononuclear Cells in Amnestic Mild Cognitive Impairment and Alzheimer’s Disease
(2022)
Recent studies suggest that cellular senescence plays a role in Alzheimer’s Disease (AD) pathogenesis. We hypothesize that cellular senescence markers might be tracked in the peripheral tissues of AD patients. Senescence ...
Analysis of cellular senescence in Spinocerebellar ataxia type 7 using bioinformatics and an inducible cell model
(Instituto Tecnológico y de Estudios Superiores de Monterrey, 2022-06-15)
Spinocerebellar ataxia type 7 (SCA7) is an autosomal dominant inherited disorder manifested by the inability to coordinate balance, gait, and speech. Some experimental evidence suggests that nuclear inclusion of mutant ...
Elimination of Radiation-Induced Senescence in the Brain Tumor Microenvironment Attenuates Glioblastoma Recurrence
(2021-12-01)
Glioblastomas (GBM) are routinely treated with ionizing radiation (IR) but inevitably recur and develop therapy resistance. During treatment, the tissue surrounding tumors is also irradiated. IR potently induces senescence, ...
Oxidative stress-induced premature senescence dysregulates VEGF and CFH expression in retinal pigment epithelial cells: Implications for Age-related Macular Degeneration
(ELSEVIER BV, 2016-04)
AbstractOxidative stress has a critical role in the pathogenesis of Age-related Macular Degeneration (AMD), a multifactorial disease that includes age, gene variants of complement regulatory proteins and smoking as the ...