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Avaliação do envolvimento da enzima monoamina oxidase B em modelos de dor pós-operatória e neuropática em camundongos
(Universidade Federal de Santa MariaBRBioquímicaUFSMPrograma de Pós-Graduação em Ciências Biológicas: Bioquímica Toxicológica, 2010-03-26)
Monoamines appear to play an important modulatory role on pain descending pathways and are involved in the antinociceptive mechanism of several drugs commonly used for the management of pain. In this study, we assessed the ...
Early impairment of cognitive functions in Parkinson's disease
(2007-06-01)
Background: Impairment in non-motor functions such as disturbances of some executive functions are also common events in Parkinson's disease patients. Objective: To verify the performance of Parkinson's disease patients ...
Early impairment of cognitive functions in Parkinson's disease
(2007-06-01)
Background: Impairment in non-motor functions such as disturbances of some executive functions are also common events in Parkinson's disease patients. Objective: To verify the performance of Parkinson's disease patients ...
Selegilina reverte a piora da memória inuzida por Aβ25-35 em camundongos: envolvimento da atividade da MAO-B
(Universidade Federal de Santa MariaBRFarmacologiaUFSMPrograma de Pós-Graduação em Farmacologia, 2013-02-28)
Alzheimer s disease (AD) is biochemically characterized by the occurrence of extracellular deposits of amyloid beta peptide (Aβ) and intracellular deposits of the hyperphosphorylated tau protein, which are causally related ...
Development and in vitro evaluation of potential electromodulated transdermal drug delivery systems based on carbon nanotube buckypapers
(Elsevier Science, 2017-07)
Buckypapers based on different types of carbon nanotubes with and without the addition of four model drugs, two of basic nature (clonidine hydrochloride, selegiline hydrochloride) and the others of acidic character ...
Small molecule-mediated stabilization of vesicle-associated helical Alpha-synuclein inhibits patogenic misfolding and aggregation
(Nature Publishing Group, 2014-12)
α-synuclein is an abundant presynaptic protein that is important for regulation of synaptic vesicle trafficking, and whose misfolding plays a key role in Parkinson’s disease. While α-synuclein is disordered in solution, ...