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Astroglial mGlu3 receptors promote alpha-secretase-mediated amyloid precursor protein cleavage
(Elsevier, 2013-11)
Amyloid precursor protein (APP) shedding yields the Alzheimer´s disease (AD)-related peptide amyloid B (AB) through beta- and gamma-secretase cleavage. Alternatively, alpha-secretase cleavage generates a soluble and ...
Gamma secretase inhibitor impairs epithelial-to-mesenchymal transition induced by TGF-β in ovarian tumor cell lines
(Elsevier Ireland, 2017-01)
Ovarian cancer is characterized by being highly metastatic, a feature that represents the main cause of failure of the treatment. This study investigated the effects of γ-secretase inhibition on the TGF-β-induced ...
Adaptor protein 2-mediated endocytosis of the beta-secretase bace1 is dispensable for amyloid precursor protein processing
(AMERICAN SOCIETY FOR CELL BIOLOGY, 2012)
Alpha-secretase-derived fragment of cellular prion, n1, protects against monomeric and oligomeric amyloid beta (a beta)-associated cell death
(AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC, 2012)
7-Amidocoumarins as Multitarget Agents against Neurodegenerative Diseases: Substitution Pattern Modulation
(John Wiley and Sons Ltd, 2020)