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Expression and processing of recombinant sarafotoxins precursor in Pichia pastoris
(Elsevier B.V., 2001-08-01)
Sarafotoxins are peptides isolated from the Atractaspisw snake venom. with strong constrictor effect on cardiac and smooth muscle. They are structurally and functionally related to endothelins. The sarafotoxins precursor ...
Expression and processing of recombinant sarafotoxins precursor in Pichia pastoris
(Elsevier B.V., 2001-08-01)
Sarafotoxins are peptides isolated from the Atractaspisw snake venom. with strong constrictor effect on cardiac and smooth muscle. They are structurally and functionally related to endothelins. The sarafotoxins precursor ...
Expression and processing of recombinant sarafotoxins precursor in Pichia pastoris
(Elsevier B.V., 2014)
Distinct endothelin-B receptors mediate the effects of sarafotoxin S6c and IRL1620 in the ileum
(Lippincott Williams & Wilkins, 1998-01-01)
In the guinea pig ileum, both sarafotoxin S6c (S6c) and IRL1620 induced a biphasic effect (relaxation and contraction). S6c induced strong tachyphylaxis of both components of the response, but IRL1620 induced tachyphylaxis ...
Effects of endothelin ETB receptor agonists and antagonists on the biphasic response in the ileum
(Elsevier B.V., 1999-03-19)
In the guinea-pig ileum, both sarafotoxin S6c and IRL1620 (Suc-[Glu(9),Ala(11,15)]endothelin-1-(8-21) induced a concentration-dependent biphasic effect (relaxation and contraction), but distinct tachyphylaxis of the tissue. ...
Endothelins modulate inflammatory reaction in zymosan-induced arthritis: participation of LTB4, TNF-alpha, and CXCL-1
(FEDERATION AMER SOC EXP BIOL, 2008)
Endothelins (ETs) are involved in inflammatory events, including pain, fever, edema, and cell migration. ET-1 levels are increased in plasma and synovial membrane of rheumatoid arthritis (RA) patients, but the evidence ...
ROLE of POSITION-9 and POSITION-10 in the ENDOTHELIN MOLECULE for BIOLOGICAL-ACTIVITY and DISCRIMINATION of RECEPTOR SUBTYPES
(Elsevier B.V., 1995-05-15)
The importance of residues 9 and 10 in endothelin-1 was assessed by studying the responses of the guinea-pig ileum to [Ala(9)]endothelin-1 and [Ala(10)]endothelin-1. Both analogues induced relaxation followed by contraction. ...