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Salsolinol e isosalsolinol : productos de la condensación de dopamina y acetaldehído como efectores finales del efecto reforzante del etanol
(Universidad de Chile, 2013-01)
Recientemente, se demostró que la metabolización de etanol a acetaldehído es indispensable para que su consumo sea reforzante; sin embargo, no se conoce el mecanismo cerebral por el cual se produce este efecto. Se ha ...
(R)-Salsolinol, a product of ethanol metabolism, stereospecifically induces behavioral sensitization and leads to excessive alcohol intake
(Wiley-Blackwell, 2016)
Ethanol is oxidized in the brain to acetaldehyde, which can condense with dopamine to generate (R/S)-salsolinol [(RS)-SAL]. Racemic salsolinol [(RS)-SAL] is self-infused by rats into the posterior ventral tegmental area ...
Salsolinol, free of isosalsolinol, exerts ethanol-like motivational/sensitization effects leading to increases in ethanol intake
(Elsevier Inc., 2014)
© 2014 Elsevier Inc.Salsolinol is formed non-enzymatically when ethanol-derived acetaldehyde binds to dopamine, yielding 2 distinct products, i.e., salsolinol and isosalsolinol. Early animal studies, revealing that salsolinol ...
Theoretical insights into the regioselectivity of a Pictet-Spengler reaction: transition state structures leading to salsolinol and isosalsolinol
(Wiley, 2017)
The mechanism of the cyclization step of the Pictet-Spengler reaction between acetaldehyde and dopamine to give salsolinol and isosalsolinol was studied computationally, using density functional theory. The preferential ...
Metabolitos del etanol con efectos en el sistema nervioso central : separación de los regioisómeros salsolinol e isosalsolinol y sus respectivos enantiómeros R y S
(Universidad de ChileCyberDocs, 2010)
Las propiedades reforzantes del etanol en el sistema nervioso central (SNC), que se postula
son responsables de la auto-administración repetida de alcohol, se deben al aumento de la
liberación de dopamina, inducido por ...
Molecular modeling of salsolinol, a full Gi protein agonist of the μ-opioid receptor, within the receptor binding site
(Blackwell Publishing Ltd, 2019)
(R/S)-Salsolinol is a full agonist of the μ-opioid receptor (μOR) Gi protein pathway via its (S)-enantiomer and is functionally selective as it does not promote β-arrestin recruitment. Compared to (S)-salsolinol, the ...
Possible role of salsolinol quinone methide in the decrease of RCSN-3 cell survival
(ACADEMIC PRESS INC, 2001-05-25)
The endogenous dopamine-derived neurotoxin salsolinol was found to decrease survival in the dopaminergic neuronal cell line RCSN-3, derived from adult rat substantia nigra in a concentration-dependent manner (208 muM ...
The "first hit" toward alcohol reinforcement: Role of ethanol metabolites
(Blackwell Publishing Ltd, 2015)
Racemic salsolinol and its enantiomers act as agonists of the µ-opioid receptor by activating the Gi protein-adenylate cyclase pathway
(Frontiers Media S.A., 2017)
© 2017 Berríos-Cárcamo, Quintanilla, Herrera-Marschitz, Vasiliou, Zapata-Torres and Rivera-Meza. Background: Several studies have shown that the ethanol-derived metabolite salsolinol (SAL) can activate the mesolimbic system, ...