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TOXICITY and RETINAL PENETRATION of INFLIXIMAB in PRIMATES

Melo, Gustavo B. [UNIFESP]; Moraes Filho, Milton N. [UNIFESP]; Rodrigues, Eduardo B. [UNIFESP]; Regatieri, Caio V. [UNIFESP]; Dreyfuss, Juliana L. [UNIFESP]; Penha, Fernando M. [UNIFESP]; Pinheiro, Marcelo M. [UNIFESP]; Coimbra, Rita C. S. G. [UNIFESP]; Haapalainen, Edna Freymuller [UNIFESP]; Farah, Michel E. [UNIFESP] (Lippincott Williams & Wilkins, 2012-03-01)

Purpose: To evaluate the retinal penetration and toxicity of two doses of intravitreal infliximab in primates.Methods: Ten marmosets (Callithrix jacchus) were given intravitreal injection of 100 mu g or 400 mu g of infliximab, ...

Neuroprotective effect of melatonin loaded in ethylcellulose nanoparticles applied topically in a retinal degeneration model in rabbits

Bessone, Carolina del Valle; Martinez, Sofía Inés; Luna, José Domingo; Márquez, Marilyn A.; Ramirez, Maria Laura; Allemandi, Daniel Alberto; Carpentieri, Agata Rita; Quinteros, Daniela Alejandra (Academic Press Ltd - Elsevier Science Ltd, 2020-11)

We are reporting for the first time the synthesis and application of an innovative nanometric system for the controlled topic release of melatonin in the retina. The ethylcellulose nanocapsules were characterized by diverse ...

Increased delivery of chemotherapy to the vitreous by inhibition of the blood-retinal barrier

Pascual-Pasto, Guillem; Olaciregui, Nagore G.; Opezzo, Javier A. W.; Castillo Ecija, Helena; Cuadrado Vilanova, Maria; Paco, Sonia; Rivero, Ezequiel Mariano; Vila Ubach, Monica; Restrepo Perdomo, Camilo A.; Torrebadell, Montserrat; Suñol, Mariona; Schaiquevich, Paula Susana; Mora, Jaume; Bramuglia, Guillermo Federico; Chantada, Guillermo Luis; Carcaboso, Angel M. (Elsevier Science, 2017-10)

Treatment of retinoblastoma -a pediatric cancer of the developing retina- might benefit from strategies to inhibit the blood-retinal barrier (BRB). The potent anticancer agent topotecan is a substrate of efflux transporters ...

Causas del desprendimiento de retina y el desenlace visual final en menores de 18 años en el Hospital San Vicente FundaciónCauses of retinal detachment and visual outcome in children under 18 years old treated at Hospital Universitario de San Vicente Fundación

Echeverry Aguilar, Claudia Andrea; Gaviria Bravo, Martha Lía (Universidad de Antioquia, Facultad de MedicinaMedellín, Colombia, 2022)

Cytoarchitecture of the avian ventral lateral geniculate nucleus

Guiloff, Gloria D.; Maturana Romesín, Humberto; Varela G., Francisco (1987)

The avian thalamic ventral lateral geniculate nucleus (GLv) was studied by light microscopic techniques in order to understand its anatomy, neuronal composition, and the nature of its retinal and tectal afferents. The avian ...

Prognostic factors in open globe injuries

Isaac, DLC; Ghanem, VC; Nascimento, MA; Torigoe, M; Kara-Jose, N (KargerBaselSuíça, 2003)

Avaliação ultra-sonográfica do segmento posterior de olhos de cães diabéticos e não diabéticos portadores de catarata

Squarzoni, Renata; Morales, Maira S.a.; Safatle, Angélica M.v.; Barros, Paulo Sérgio M. (Colégio Brasileiro de Patologia Animal - CBPAEmpresa Brasileira de Pesquisa Agropecuária (EMBRAPA), 2007-11-01)

Cataracts jeopardize the light penetration into the eye and may restrain direct exam of eye structures. It is necessary to identify very early any eye disease that could cause the failure of cataract surgery. The ocular ...

Avaliação do dano ocular após queimadura química grave na córnea e suas possíveis implicações no implante da ceratoprótese de boston

Jorge, Fabiano Cade [UNIFESP] (Universidade Federal de São Paulo (UNIFESP), 2015-12-31)

A severe chemical burn to the eye usually results in an opaque cornea. Its prognosis depends on the immediate treatment and prevention of further complications. Regardless of medical efforts, surgical rehabilitation with ...

Optical Coherence Tomography Of Macular Atrophy Associated With Microcephaly And Presumed Intrauterine Zika Virus Infection

de Moura Campos; Adriana Gondim; Cavalcanti Lira; Rodrigo Pessoa; Faria e Arantes; Tiago Eugenio (Consel Brasil OftalmologiaSão Paulo, 2016)

Factores asociados que intervienen en el pronóstico visual de los pacientes vitrectomizados por cuerpo extraño intraocular en el INO

Escobedo Arriola, Robinson Richard (Universidad Nacional Mayor de San MarcosPE, 2009)

Objetivo: Determinar los factores relacionados al mal pronóstico visual de los pacientes con diagnóstico de Trauma ocular penetrante asociado a cuerpo extraño intraocular del Segmento Posterior (CEIO) en el Instituto ...