Buscar
Mostrando ítems 1-10 de 720
Application of in vitro Drug Metabolism Studies in Chemical Structure Optimization for the Treatment of Fibrodysplasia Ossificans Progressiva (FOP)
(Frontiers Media Sa, 2019-04-24)
Currently no approved treatment exists for fibrodysplasia ossificans progressiva (FOP) patients, and disease progression results in severe restriction of joint function and premature mortality. LDN-193189 has been demonstrated ...
Can trifluoperazine protect mitochondria against reactive oxygen species-induced damage?
(1996-12-01)
Trifluoperazine (TFP) (35 μM) prevents mitochondrial transmembrane potential (ΔΨ) collapse and swelling induced by 10 μM Ca2+ plus oxyradicals generated from δ-aminolevulinic acid autoxidation. In contrast with EGTA, TFP ...
Can trifluoperazine protect mitochondria against reactive oxygen species-induced damage?
(1996-12-01)
Trifluoperazine (TFP) (35 μM) prevents mitochondrial transmembrane potential (ΔΨ) collapse and swelling induced by 10 μM Ca2+ plus oxyradicals generated from δ-aminolevulinic acid autoxidation. In contrast with EGTA, TFP ...
Comparative effects of fipronil and its metabolites sulfone and desulfinyl on the isolated rat liver mitochondria
(Elsevier B. V., 2015)
Fipronil is an insecticide extensively used to control pests in crops and animals. There are relates of poisoning due to exposure of fipronil in mammals and the liver has been suggested as potential target. In this study, ...
Pathophysiology of mesenteric ischemia/reperfusion: a review.
(2005-07-01)
During ischemia, the cell structures are progressively damaged, but restoration of the blood flow, paradoxically, intensifies the lesions caused by the ischemia. The mechanisms of ischemia injury and reperfusion (I/R) have ...