Buscar
Mostrando ítems 1-10 de 139
Medicamentos judicializados na região central do estado do Rio Grande do Sul
(Universidade Federal de Santa MariaBrasilMedicinaUFSMPrograma de Pós-Graduação em Ciências da SaúdeCentro de Ciências da Saúde, 2014-11-25)
Brazilian society experiences a substantial increase in the consumption of drugs and conflicts involving access to these therapeutic resources. In the judicial sphere, processes directed towards access to medicines and ...
MRP4/ABCC4 as a new therapeutic target: meta-analysis to determine cAMP binding sites as a tool for drug design
(Bentham Science Publishers, 2017-12)
MRP4 transports multiple endogenous and exogenous substances and is critical not only for detoxification but also in the homeostasis of several signaling molecules. Its dysregulation has been reported in numerous pathological ...
The Thiol-polyamine Metabolism of Trypanosoma cruzi: Molecular Targets and Drug Repurposing Strategies
(Bentham Science Publishers, 2018-09)
Chagas´ disease continues to be a challenging and neglected public health problem in many American countries. The etiologic agent, Trypanosoma cruzi, develops intracellularly in the mammalian host, which hinders treatment ...
Mesoporous silica nanocarriers encapsulated antimalarials with high therapeutic performance
(Nature Research, 2019)
Advances in the use of MOFs for cancer diagnosis and treatment: An overview
(2020-01-01)
Nanoparticles as drug delivery systems and diagnostic agents have gained much attention in recent years, especially for cancer treatment. Nanocarriers improve the therapeutic efficiency and bioavailability of antitumor ...
Fragment-Based QSAR and Molecular Modeling Studies on a Series of Discodermolide Analogs as Microtubule-Stabilizing Anticancer Agents
(WILEY-V C H VERLAG GMBH, 2009)
Inhibition of microtubule function is an attractive rational approach to anticancer therapy. Although taxanes are the most prominent among the microtubule-stabilizers, their clinical toxicity, poor pharmacokinetic properties, ...
Search of vasopressin analogs with antiproliferative activity on small-cell lung cancer: Drug design based on two different approaches
(Future Medicine, 2018-04)
Aim: Development of compounds with therapeutic application requires the interaction of different disciplines. Several tumors express vasopressin (AVP; arginine vasopressin) receptors with contrasting effects depending on ...
Abordagem racional no planejamento de novos tuberculostáticos: inibidores da InhA, enoil-ACP redutase do M. tuberculosisRational approach in the new antituberculosis agent design: inhibitors of InhA, the enoyl-ACP reductase from Mycobacterium tuberculosis
(Divisão de Biblioteca e Documentação do Conjunto das Químicas da Universidade de São PauloBrasil, 2008)