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Experimental Studies 1st Part. Clinical Trial [Estudios experimentales 1ª parte. El ensayo clínico]
(Universidad de la Frontera, 2015)
Initiation and continuation of randomized trials after the publication of a trial stopped early for benefit asking the same study question: STOPIT-3 study design
(BioMed Central, 2013)
Background: Randomized control trials (RCTs) stopped early for benefit (truncated RCTs) are increasingly common and, on average, overestimate the relative magnitude of benefit by approximately 30%. Investigators stop trials ...
Randomized trials addressing a similar question are commonly published after a trial stopped early for benefit
(Elsevier, 2017)
Objective: We explored how investigators of ongoing or planned trials respond to the publication of a trial stopped early for benefit addressing a similar question. Study Design and Setting: We searched multiple databases ...
The Latin American ongoing clinical trial register (LATINREC)
(PAN AMER HEALTH ORGANIZATION, 2006)
Limits to clinical trials in surgical areas
(Faculdade de Medicina / USP, 2011)
Randomized clinical trials are considered to be the gold standard of evidence-based medicine nowadays. However, it is important that we point out some limitations of randomized clinical trials relating to surgical ...
Botanical drug clinical trial: common issues and future options
Botanical drugs are plant-derived, complex mixtures which may have synergistic effects.
In order to understand this disparity between human use and drugs approved by regulatory agencies,
we analyzed botanical drug clinical ...