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Crystal structure of Schistosoma purine nucleoside phosphorylase complexed with a novel monocyclic inhibitor
(ELSEVIER SCIENCE BV, 2010)
A novel inhibitor of Schistosoma PNP was identified using an ""in silico"" approach allied to enzyme inhibition assays. The compound has a monocyclic structure which has not been previously described for PNP inhibitors The ...
Capillary bioreactors based on human purine nucleoside phosphorylase: A new approach for ligands identification and characterization
(ELSEVIER SCIENCE BVAMSTERDAM, 2012)
The enzyme purine nucleoside phosphorylase (PNP) is a target for the discovery of new lead compounds employed on the treatment severe T-cell mediated disorders. Within this context, the development of new, direct, and ...
Developing a collection of immobilized nucleoside phosphorylases for the preparation of nucleoside analogues: Enzymatic synthesis of arabinosyladenine and 2',3'-dideoxyinosine
(Wiley, 2013-02)
The use of nucleoside phosphorylases (NPs; EC 2.4.2.n) represents a convenient alternative to the chemical route for the synthesis of natural and modified nucleosides. We purified four recombinantly expressed nucleoside ...
First synthesis of (-)-neplanocin C
(Pergamon-Elsevier Science Ltd, 2000-06)
(-)-Neplanocin C (4), a minor component of the neplanocin family of antibiotics and a lead drug for the design of several conformationally constrained nucleosides analogues, was enantioselectively synthesized starting from ...
Adenosine binding to low-molecular-weight purine nucleoside phosphorylase: the structural basis for recognition based on its complex with the enzyme from Schistosoma mansoni
(WILEY-BLACKWELL PUBLISHING, INC, 2010)
Schistosomes are unable to synthesize purines de novo and depend exclusively on the salvage pathway for their purine requirements. It has been suggested that blockage of this pathway could lead to parasite death. The enzyme ...
2′-Deoxyribosyltransferase from Leishmania mexicana, an efficient biocatalyst for one-pot, one-step synthesis of nucleosides from poorly soluble purine bases
(Applied Microbiology and Biotechnology, 2018)