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An Overview of the Role of Molecular Chaperones in Protein Homeostasis
(Bentham Science Publ LtdSharjahEmirados Árabes Unidos, 2011)
Glycoprotein Folding and Processing Reactions
(Academic Press Inc Elsevier Science, 2013)
The N-glycan-dependent quality control of glycoprotein folding occurring in the endoplasmic reticulum prevents exit to Golgi of folding intermediates, irreparably misfolded glycoproteins, and incompletely assembled multimeric ...
Quality Control in Glycoprotein Folding
(Wiley-VCH, 2005)
The concept of quality control of protein folding in the secretory pathway emerged in the late 1970s and early 1980s when it was noticed that not in all cases did insertion of proteins in the endoplasmic reticulum (ER) ...
Protein folding stress in neurodegenerative diseases: a glimpse into the ER
(CURRENT BIOLOGY LTD, 2011-03)
Several neurodegenerative diseases share common neuropathology, primarily featuring the presence in the brain of abnormal protein inclusions containing specific misfolded proteins. Recent evidence indicates that alteration ...
Endoplasmic Reticulum-Associated Degradation and Protein Quality Control
(Elsevier Academic Press Inc, 2016)
Approximately one-third of all polypeptides synthesized in eukaryotes are targeted to the endoplasmic reticulum (ER), and once associated with this compartment they are chemically modified. The folding status of the ...
Glycans in Glycoprotein Quality Control
(Cold Spring Harbor Laboratory Press, 2009)
Nglycans help glycoproteins fold by creating a series of checkpoints that dictate the life or the death of newly made membrane and secreted proteins. This chapter describes the quality control process in the endoplasmic ...
Progesterone regulates the expression and activity of two mouse isoforms of the glycoprotein folding sensor UDP-Glc: Glycoprotein glucosyltransferase (UGGT)
(Elsevier Science, 2013-12)
UDP-Glucose:glycoprotein glucosyltransferase (UGGT) is a central component of the endoplasmic reticulum (ER) glycoprotein-folding quality control system, which prevents the exit of partially folded species. UGGT activity ...
Characterization of folding-sensitive nanobodies as tools to study the expression and quality of protein particle immunogens
(Elsevier Science, 2019-03)
Vaccination is as one of the most beneficial biopharmaceutical interventions against pathogens due to its ability to induce adaptive immunity through targeted activation of the immune system. Each vaccine needs a tailor-made ...
Glycoprotein Tertiary and Quaternary Structures Are Monitored by the Same Quality Control Mechanism
(American Society for Biochemistry and Molecular Biology, 2005-05)
Folding of glycoproteins entering the secretory pathway is strictly surveyed in the endoplasmic reticulum by a quality control system. Folding intermediates and proteins irreparably misfolded are marked via glucosylation ...