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HIV-1 Tat protein enhances the intracellular growth of Leishmania amazonensis via the ds-RNA induced protein PKR
(Nature Publishing Group, 2016)
Regulação da expressão da proteína cinase PKR na ausência de interferons(IFNs) e seu papel na resposta celular mediada por agonistas dos receptoresTLR2 e TLR4
(Universidade Federal de Minas GeraisUFMG, 2012-08-10)
The role of protein kinase R (PKR) in the antiviral cell state induced byinterferons (IFNs) is well known. The increase in its expression in response to stimulation by IFNs results in its autophosphorylation and phosphorylation ...
Novel role for the double-stranded RNA-activated protein kinase PKR: modulation of macrophage infection by the protozoan parasite Leishmania
(Federation of American Society of Experimental Biology, 2018)
Non-coding transcript in T cells (NTT): Antisense transcript activates PKR and NF-kappa B in human lymphocytes
(ACADEMIC PRESS INC ELSEVIER SCIENCE, 2008)
T cell activation is a complex process involving many steps and the role played by the non-protein-coding RNAs (ncRNAs) in this phenomenon is still unclear. The non-coding T cells transcript (NTT) is differentially expressed ...
Double-Stranded RNA-Activated Protein Kinase Is a Key Modulator of Insulin Sensitivity in Physiological Conditions and in Obesity in Mice
(ENDOCRINE SOCCHEVY CHASE, 2012)
The molecular integration of nutrient-and pathogen-sensing pathways has become of great interest in understanding the mechanisms of insulin resistance in obesity. The double-stranded RNA-dependent protein kinase (PKR) is ...
Glycogen synthase kinase (GSK)-3 and the double-strand RNA-dependent kinase, PKR: When two kinases for the common good turn bad
Glycogen synthase kinase (GSK)-3α/β and the double-stranded RNA-dependent kinase PKR are two sentinel
kinases that carry-out multiple similar yet distinct functions in both the cytosol and the nucleus. While these
kinases ...
Protein kinase R is an innate immune sensor of proteotoxic stress via accumulation of cytoplasmic IL-24
(2022)
Proteasome dysfunction can lead to autoinflammatory disease associated with elevated type I interferon (IFN-αβ) and NF-κB signaling; however, the innate immune pathway driving this is currently unknown. Here, we identified ...
The Potential Role of Protein Kinase R as a Regulator of Age-Related Neurodegeneration
(2021-04-28)
There is a growing evidence describing a decline in adaptive homeostasis in aging-related diseases affecting the central nervous system (CNS), many of which are characterized by the appearance of non-native protein aggregates. ...