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The preclinical discovery and development of opicapone for the treatment of Parkinson’s disease
(Taylor and Francis Ltd, 2020)
CYP450 Metabolism of a Semisynthetic Naphthoquinone, an Anticancer Drug Candidate, by Human Liver Microsomes
(Soc Brasileira Quimica, 2022-02-21)
CNFD (6b,7-dihydro-5H-cyclopenta[b]naphtho[2,1-d]furan-5,6(9aH)-dione) is a semisynthetic naphthoquinone derived from lawsone that has cytotoxic action in different tumor lines and anticancer activity in vivo. Therefore, ...
Treatment of fibrinolytic alveolitis with rifamycin B diethylamide associated with gelfoam: a histological study.
(1997-12-01)
The most common complication in the healing of extraction wounds is fibrinolytic alveolitis, which may also be termed dry socket. Reduction in the incidence of this condition after the application of topical antibiotics ...
Treatment of fibrinolytic alveolitis with rifamycin B diethylamide associated with gelfoam: a histological study.
(1997-12-01)
The most common complication in the healing of extraction wounds is fibrinolytic alveolitis, which may also be termed dry socket. Reduction in the incidence of this condition after the application of topical antibiotics ...
A review of pharmacokinetic parameters of metabolites and prodrugs
(Drug Metabolism Letters, 2014)
In drug discovery and development, the kinetic study of active metabolites plays an important role, helping to define the time course of the drug in the body and its activity or toxicity. After a pharmacokinetics assessment ...
Role of ticlopidine on adriamycin-induced nephropathy
(1999-10-11)
The effect of ticlopidine on rats with adriamycin nephropathy was observed during 26 weeks. In the ticlopidine-treated nephrotic animals (TNG), proteinuria was less than in the untreated nephrotic animals (NG), but this ...