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An acetylation site in lectin domain modulates the biological activity of polypeptide GalNAc-transferase-2
(De Gruyter, 2012-12)
Polypeptide GalNAc-transferases (ppGalNAc-Ts) are a family of enzymes that catalyze the initiation of mucintype O -glycosylation. All ppGalNAc-T family members contain a common (QXW) 3 motif, which is present in the R-type ...
Functional control of polypeptide GalNAc-transferase 3 through an acetylation site in the C-terminal lectin domain
(De Gruyter, 2017-01)
O-GalNAc glycans are important structures in cellular homeostasis. Their biosynthesis is initiated by members of the polypeptide GalNAc-transferase (ppGalNAc-T) enzyme family. Mutations in ppGalNAc-T3 isoform cause diseases ...
Catalytic and glycan-binding abilities of ppGalNAc-T2 are regulated by acetylation
(Academic Press Inc Elsevier Science, 2011-06)
Post-translational acetylation is an important molecular regulatory mechanism affecting the biological activity of proteins. Polypeptide GalNAc transferases (ppGalNAc-Ts) are a family of enzymes that catalyze initiation ...
Extrinsic functions of lectin domains in O-N-acetylgalactosamine glycan biosynthesis
(American Society for Biochemistry and Molecular Biology, 2016-12)
Glycan biosynthesis occurs mainly in Golgi. Molecular organization and functional regulation of this process are not well understood. We evaluated the extrinsic effect of lectin domains (β-trefoil fold) of polypeptide ...
Introducción al análisis estructural de proteínas y glicoproteínas
(Sede BogotáBogotá, Colombia, 2020-05)
Los seres vivos están conformados por gran diversidad de proteínas con diferentes características físicas, químicas, estructurales y funcionales. Para entender la función de una proteína se necesita conocer su secuencia ...
Identificación de mutaciones en genes asociados a canalopatías hereditarias mediante análisis exómico
(Universidad Nacional de ColombiaBogotá - Ciencias - Doctorado en Ciencias - BiologíaFacultad de CienciasBogotá, ColombiaUniversidad Nacional de Colombia - Sede Bogotá, 2023-05-31)
El estudio de muerte súbita cardiaca es muy importante, dada la alta incidencia a nivel mundial, y en los países industrializados se ha convertido un problema de salud pública. Sin embargo, el abordaje de este tipo de ...
Evaluación de miRNAs en la línea celular de melanoma B16 inducida a pigmentación diferencial y disminución del crecimiento celular por la L-Tirosina y la 5-bromo-2´-deoxiuridina
(Bogotá - Medicina - Doctorado en Ciencias BiomédicasUniversidad Nacional de Colombia - Sede Bogotá, 2020-12-04)
miRNAs are small non-coding RNAs associated with post-transcriptional gene regulation in melanoma, a cancer of melanocytes, cells specialized in melanin synthesis. The present work aimed to evaluate the differential ...