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Molecular evolution, mutation size and gene pleiotropy: a geometric reexamination
(GENETICS SOC AM, 2011)
Actors with Multiple Roles: Pleiotropic Enhancers and the Paradigm of Enhancer Modularity
(Elsevier Science London, 2019-06)
The current paradigm in the field of gene regulation postulates that regulatory information for generating gene expression is organized into modules (enhancers), each containing the information for driving gene expression ...
Comprehensive Analysis of a cis-Regulatory Region Reveals Pleiotropy in Enhancer Function
(Elsevier, 2018-03)
Developmental genes can have complex cis-regulatory regions with multiple enhancers. Early work revealed remarkable modularity of enhancers, whereby distinct DNA regions drive gene expression in defined spatiotemporal ...
Pleiotropy in developmental regulation by flowering‐pathway genes: is it an evolutionary constraint?
(Wiley Blackwell Publishing, Inc, 2019-10)
Pleiotropy occurs when one gene influences more than one trait, contributing to genetic correlations among traits. Consequently, it is considered a constraint on the evolution of adaptive phenotypes because of potential ...
MODULARITY, NOISE, AND NATURAL SELECTION
(WILEY-BLACKWELLMALDEN, 2012)
Most biological systems are formed by component parts that are to some degree interrelated. Groups of parts that are more associated among themselves and are relatively autonomous from others are called modules. One of the ...
Herança de hilo esparramado em sementes de soja.
(Pesquisa Agropecuária Brasileira, Brasília, v.42, n. 1, p.127-129, jan. 2007., 2011)
Clinical pleiomorphism in human leishmaniases, with special mention of asymptomatic infection
(Elsevier, 2011)
This review gives an update of current knowledge on the clinical pleiomorphism of Leishmania, with a special emphasis on the case of asymptomatic carriage. The first part describes the numerous unusual expressions of the ...