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RSUME is implicated in HIF-1-induced VEGF-A production in pituitary tumour cells
(Bioscientifica, 2012-02)
The recently cloned small RWD-domain containing protein RSUME was shown to increase protein levels of hypoxia-inducible factor-1a (HIF-1a). The latter is the oxygen-regulated subunit of HIF-1, the most important transcription ...
Translational research in pituitary tumours
(BioScientifica, 2019-12)
Although effective treatment regimens (surgical resection, drug treatment with dopamine agonists or somatostatin analogues, radiotherapy) have been established for the therapy of most pituitary tumours, a considerable ...
The ERα membrane pool modulates the proliferation of pituitary tumours
(BioScientifica, 2019-02)
The molecular mechanisms underlying the ERα nuclear/cytoplasmic pool that modulates pituitary cell proliferation have been widely described, but it is still not clear how ERα is targeted to the plasma membrane. The aim of ...
Pivotal role of NF-κB in cellular senescence of experimental pituitary tumours
(BioScientifica, 2020-05)
The molecular mechanisms underlying the capability of pituitary tumours to avoid unregulated cell proliferation are still not well understood. However, the NF-κB transcription factor, which is able to modulate not only ...
Oxidative stress and mitochondrial adaptive shift during pituitary tumoral growth
(Elsevier Science Inc, 2018-05)
The cellular transformation of normal functional cells to neoplastic ones implies alterations in the cellular metabolism and mitochondrial function in order to provide the bioenergetics and growth requirements for tumour ...
Curcumin suppresses HIF1A synthesis and VEGFA release in pituitary adenomas
(BioScientifica, 2012-09)
Curcumin (diferuloylmethane), a polyphenolic compound derived from the spice plant Curcuma longa, displays multiple actions on solid tumours including anti-angiogenic effects. Here we have studied in rodent and human ...
Gender differences in the expression of galanin and vasoactive intestinal peptide in oestrogen-induced prolactinomas of Fischer 344 rats
(Cell Press, 2004)
We have previously described a sexual dimorphism in oestrogen-induced anterior pituitary tumorigenesis in Fischer 344 rats, with female tumours averaging twice the size of those of males. Neonatal androgenization of female ...
Involvement of the gp130 cytokine transducer in MtT/S pituitary somatotroph tumour development in an autocrine-paracrine model
(BioScientifica, 2004-11)
OBJECTIVE: gp130 cytokines are placed as auto-paracrine regulators of pituitary function, since they, as well as their receptors, have been shown to be expressed in and to act in normal and tumoral anterior pituitary cells. ...
Predictive factors for the development of visual loss in patients with pituitary macroadenomas and for visual recovery after optic pathway decompression
(CANADIAN OPHTHAL SOC, 2010)
Objective: To investigate clinical and MRI findings that are predictive of both visual loss in patients with pituitary adenomas and visual recovery after treatment. Design: Cohort study. Participants: Thirty patients (60 ...
Association of PTP4A3 expression and tumour size in functioning pituitary adenoma: A descriptive study
(B M J Publishing Group, 2021-03)
PTP4A3 is a subclass of a protein tyrosine phosphatase super family and is expressed in a range of epithelial neoplasms. We evaluated PTP4A3 expression and its association with clinical-pathological parameters in different ...