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Regulación de la expresión génica mediada por piRNA en Gametogenesis masculina de mamíferos
(Universidad de Valparaíso, 2016-04)
A un grupo de RNAs pequeños no codificantes de proteínas se les ha denominado RNA interferentes, debido a la capacidad que tienen éstas moléculas para suprimir o disminuir la expresión de genes específicos mediante mecanismos ...
Evolutionary implications of the microRNA- and piRNA complement of Lepidodermella squamata (Gastrotricha)
(MDPI, 2019)
Gastrotrichs—’hairy bellies’—are microscopic free-living animals inhabiting marine and freshwater habitats. Based on morphological and early molecular analyses, gastrotrichs were placed close to nematodes, but recent ...
Reprogramming of small noncoding RNA populations in peripheral blood reveals host biomarkers for latent and active Mycobacterium tuberculosis infection
(American Society for Microbiology, 2019)
snoRNA and piRNA expression levels modified by tobacco use in women with lung adenocarcinoma
(Public Library of Science, 2018)
Non-coding RNA fragments account for themajority of annotated piRNAs expressed in somaticnon-gonadal tissues
(Nature Publishing Group, 2018)
PIWI-interacting RNAs (piRNAs) are regarded as the guardians of the genome because theytackle genome stability-threatening transposable elements in the germline. Recently, piRNAswere also reported in other types of cells, ...
Circulating SNORD57 rather than piR-54265 is a promising biomarker for colorectal cancer: common pitfalls in the study of somatic piRNAs in cancer
(RNA Society, 2021)
There is increasing interest among cancer researchers in the study of Piwi-interacting RNAs (piRNAs), a group of small RNAs important for maintaining genome stability in the germline. Aberrant expression of piRNAs in cancer ...
Acute physical exercise increases APPL1/PI3K signaling in the hypothalamus of lean mice
(2019-01-01)
Adiponectin is an adipokine that acts in the control of energy homeostasis. The adaptor protein containing the pleckstrin homology domain, phosphotyrosine-binding domain, and leucine zipper motif 1 (APPL1) is a key protein ...
Activation of the PI3K/AKT pathway by microRNA-22 results in CLL B-cell proliferation
(Nature Publishing Group, 2015-01)
Chronic lymphocytic leukemia (CLL) is characterized by accumulation of clonal B cells arrested in G0/G1 stages that coexist, in different proportions, with proliferative B cells. Understanding the crosstalk between the ...
Controle epigenético do elemento de transposição mariner em populações de Drosophila melanogaster
(Universidade Federal de Santa MariaBrasilBioquímicaUFSMPrograma de Pós-Graduação em Biodiversidade AnimalCentro de Ciências Naturais e Exatas, 2016-05-31)
One of transposons families most well-known is the mariner family. mariner is not found in natural populations of Drosophila melanogaster, however, white-peach mariner and Mos1 were introduced in this species by genetic ...
Knockdown of host antioxidant defense genes enhances the effect of Glucantime on intracellular Leishmania braziliensis in Human Macrophages
(American Society for Microbiology, 2018)