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Molecular interplays in hepatic stellate cells: apoptosis, senescence, and phenotype reversion as cellular connections that modulate liver fibrosis
(Wiley-Blackwell, 2017-09-01)
Liver fibrosis is a pathophysiological process correlated with intense repair and cicatrization mechanisms in injured liver, and over the past few years, the characterization of the fine-tuning of molecular interconnections ...
Application of crispr/cas9-based reverse genetics in leishmania braziliensis: Conserved roles for hsp100 and hsp23
(MDPI, 2020)
The protozoan parasite Leishmania (Viannia) braziliensis (L. braziliensis) is the main cause of human tegumentary leishmaniasis in the New World, a disease affecting the skin and/or mucosal tissues. Despite its importance, ...
Cloning of glucocorticoid-regulated genes in C6/ST1 rat glioma phenotypic reversion
(1996-01-01)
The C6 rat glioma cell line is responsive to glucocorticoid hormones. C6 variants that are hyper-responsive (ST1) and resistant (P7) to hormone treatment have been derived previously. Glucocorticoid treatment of ST1 cells ...
Cloning of glucocorticoid-regulated genes in C6/ST1 rat glioma phenotypic reversion
(1996-01-01)
The C6 rat glioma cell line is responsive to glucocorticoid hormones. C6 variants that are hyper-responsive (ST1) and resistant (P7) to hormone treatment have been derived previously. Glucocorticoid treatment of ST1 cells ...
Weak phenotypic reversion of ivermectin resistance in a field resistant isolate of Haemonchus contortus by verapamil
(Colégio Brasileiro de Patologia Animal - CBPA, 2011-09-01)
Avanços recentes na reversão fenotípica da resistência anti-helmíntica por drogas moduladoras de Pgp em nematódeos de ruminantes indicam que esta pode ser uma ferramenta útil no controle de helmintos. O objetivo do presente ...
Weak phenotypic reversion of ivermectin resistance in a field resistant isolate of Haemonchus contortus by verapamil
(Colégio Brasileiro de Patologia Animal - CBPA, 2011-09-01)
Avanços recentes na reversão fenotípica da resistência anti-helmíntica por drogas moduladoras de Pgp em nematódeos de ruminantes indicam que esta pode ser uma ferramenta útil no controle de helmintos. O objetivo do presente ...
The modulatory effect of triclosan on the reversion of the activated phenotype of LX-2 hepatic stellate cells
(Wiley-Blackwell, 2019-11-12)
Hepatic diseases leading to fibrosis affect millions of individuals worldwide and are a major public health challenge. Although, there have been many advances in understanding hepatic fibrogenesis, an effective therapy ...
Weak phenotypic reversion of ivermectin resistance in a field resistant isolate of Haemonchus contortus by verapamil
(Colégio Brasileiro de Patologia Animal - CBPA, 2014)
Reversible behavioral phenotypes in a conditional mouse model of TDP-43 proteinopathies
(Society for Neuroscience, 2014-11)
Transactive response DNA-binding protein 43 (TDP-43) mislocalization and aggregation are hallmark features of amyotrophic lateral sclerosis and frontotemporal dementia (FTD). We have previously shown in mice that inducible ...