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Metabolic and Inflammatory Adaptation of Reactive Astrocytes: Role of PPARs
(Humana Press Inc., 2017)
Ligand- and Structure-Based Drug Design Strategies and PPAR delta/alpha Selectivity
(Wiley-BlackwellHoboken, 2012)
Peroxisome-proliferator-activated receptors are a class of nuclear receptors with three subtypes: a, ? and d. Their main function is regulating gene transcription related to lipid and carbohydrate metabolism. Currently, ...
Endothelial PPARγ Is Crucial for Averting Age-Related Vascular Dysfunction by Stalling Oxidative Stress and ROCK
(Springer New York LLC, 2019)
Megalin/LRP2 Expression is induced by peroxisome proliferator-activated receptor-alpha and –gamma: Physiopathological implications for kidney function
(2009)
BACKGROUND: Megalin is a large endocytic receptor with relevant functions during development and adult life. It is expressed at the apical surface of several epithelial cell types, including proximal tubule cells (PTCs) ...
P450CYP2C epoxygenase and CYP4A omega-hydroxylase mediate ciprofibrate-induced PPAR alpha-dependent peroxisomal proliferation
(AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC, 2007)
Peroxisomal proliferators, such as ciprofibrate, are used extensively as effective hypolipidemic drugs. The effects of these compounds on lipid metabolism require ligand binding activation of the peroxisome proliferator-activated ...