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Development of an operational substrate for ZapA, a metalloprotease secreted by the bacterium Proteus mirabilis
(Associação Brasileira de Divulgação Científica (ABRADIC), 2000-07-01)
The protease ZapA, secreted by Proteus mirabilis, has been considered to be a virulence factor of this opportunistic bacterium. The control of its expression requires the use of an appropriate methodology, which until now ...
Specificity of human tissue kallikrein towards substrates containing Phe-Phe pair of amino acids
(Portland Press, 1999-04-15)
We have explored in detail the determinants of specificity for the hydrolysis by human tissue kallikrein (hK(1)) of substrates containing the Phe-Phe amino acid pair, after which hK(1) cleaves kallistatin (human ...
Development of an operational substrate for ZapA, a metalloprotease secreted by the bacterium Proteus mirabilis
(Associação Brasileira de Divulgação Científica (ABRADIC), 2014)
ZapA, a possible virulence factor from Proteus mirabilis exhibits broad protease substrate specificity
(Associação Brasileira de Divulgação Científica (ABRADIC), 2001-11-01)
The opportunistic bacterium Proteus mirabilis secretes a metalloprotease, ZapA, considered to be one of its virulence factors due to its IgA-degrading activity. However, the substrate specificity of this enzyme has not yet ...
ZapA, a possible virulence factor from Proteus mirabilis exhibits broad protease substrate specificity
(Associação Brasileira de Divulgação Científica (ABRADIC), 2001-11-01)
The opportunistic bacterium Proteus mirabilis secretes a metalloprotease, ZapA, considered to be one of its virulence factors due to its IgA-degrading activity. However, the substrate specificity of this enzyme has not yet ...
Analysis of catalytic properties of tripeptidyl peptidase I (TTP-I), a serine carboxyl lysosomal protease, and its detection in tissue extracts using selective FRET peptide substrate
(Elsevier Science Inc, 2016)
Tripeptidyl peptidase I (TPP-I), also named ceroid lipofuscinosis 2 protease (CLN2p), is a serine carboxyl lysosomal protease involved in neurodegenerative diseases, and has both tripeptidyl amino- and endopeptidase ...
Changes of enzyme activity in lipid signaling pathways related to substrate reordering
(BIOPHYSICAL SOCIETY, 2005-08)
The static fluid mosaic model of biological membranes has been progressively complemented by a dynamic membrane model that includes phospholipid reordering in domains that are proposed to extend from nanometers to microns. ...
ZapA, a possible virulence factor from Proteus mirabilis exhibits broad protease substrate specificity
(Associação Brasileira de Divulgação Científica (ABRADIC), 2014)
High resolution analysis of snake venom metalloproteinase (SVMP) peptide bond cleavage specificity using proteome based peptide libraries and mass spectrometry
(2011-04-01)
Both serine and metalloproteinases have been shown to play the role of toxins in the venoms of many snakes. Determination of the natural protein substrates of these toxins is an important feature in the toxinological ...
High resolution analysis of snake venom metalloproteinase (SVMP) peptide bond cleavage specificity using proteome based peptide libraries and mass spectrometry
(2011-04-01)
Both serine and metalloproteinases have been shown to play the role of toxins in the venoms of many snakes. Determination of the natural protein substrates of these toxins is an important feature in the toxinological ...