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Conformational transition of Aβ42 inhibited by a mimetic peptide. A molecular modeling study using QM/MM calculations and QTAIM analysis
(Elsevier, 2016-03)
The main pathogenic event in Alzheimer's disease is believed to be the aggregation of the amyloid β-peptides into toxic aggregates. In a previous work we designed a mimetic peptide possessing a significant aggregation ...
Searching for improved mimetic peptides inhibitors preventing conformational transition of amyloid-β 42 monomer
(Academic Press Inc Elsevier Science, 2018-12)
A series of novel mimetic peptides were designed, synthesised and biologically evaluated as inhibitors of Aβ 42 aggregation. One of the synthesised peptidic compounds, termed compound 7 modulated Aβ 42 aggregation as ...
Annexin A1 mimetic peptide controls the inflammatory and fibrotic effects of silica particles in mice
(The British Pharmacological SOcity, 2015)
The effects of the C-terminal amidation of mastoparans on their biological actions and interactions with membrane-mimetic systems
(Elsevier B.V., 2014-10-01)
Polycationic peptides may present their C-termini in either amidated or acidic form; however, the effects of these conformations on the mechanisms of interaction with the membranes in general were not properly investigated ...
New mimetic peptides inhibitors of Аb aggregation. Molecular guidance for rational drug design
(Elsevier, 2015-05)
A new series of mimetic peptides possessing a significant Aβ aggregation modulating effect was reported here. These compounds were obtained based on a molecular modelling study which allowed us to perform a structural-based ...
Mimetic peptide AC2-26 of annexin A1 as a potential therapeutic agent to treat COPD
(2018-10-01)
Chronic obstructive pulmonary disease (COPD) is related to inflammatory process caused by smoking habit. In this scenario, the anti-inflammatory protein Annexin A1 (AnxA1) may represent a therapeutic alternative. We performed ...
Effect of dimerization on the mechanism of action of aurein 1.2
(2016-06-01)
The mechanism of action of antimicrobial peptides depends on physicochemical properties such as structure, concentration, and oligomerization. Here, we focused on the effect of dimerization on the mechanism of action of ...