Background: Odor transduction, occurring in the chemosensory cilia of vertebrate olfactory sensory neurons, is triggered by guanosine triphosphate-coupled odor receptors and mediated by a cyclic adenosine monophosphate ...

The signaling pathway mediating odor transduction in the chemosensory cilia of olfactory sensory neurons involves cationic cyclic nucleotide-gated channels (CNGs), opened by cyclic AMP. Ca2+ entering through CNG opens ...

Olfactory sensory neurons are able to detect odorants with high sensitivity and specificity. We have demonstrated that Ric-8B, a guanine nucleotide exchange factor (GEF), interacts with G alpha olf and enhances odorant ...

Odor transduction takes place in the cilia of olfactory sensory neurons (OSNs) of the olfactory epithelium, where they are surrounded by sustentacular cells (SCs) and covered by a mucus layer. Upon odorant binding, an odor ...

The olfactory and the vomeronasal system are the two major chemosensory systems found in terrestrial vertebrates. Among tetrapods, amphibians are unique in having an aquatic larval stage, followed by metamorphosis to a ...

Odor transduction in the cilia of olfactory sensory neurons involves several ATP-requiring enzymes. ATP is generated by glycolysis in the ciliary lumen, using glucose incorporated from surrounding mucus, and by oxidative ...

Enormous advances have been made in the recent years in regard to the mechanisms and neural circuits by which odors are sensed and perceived. Part of this understanding has been gained from parallel studies in insects and ...

Olfactory cilia (~60 μm long, 0.2 μm diameter) project from the apical knob of the single dendrite of olfactory sensory neurons (OSNs). Odorants binding to G-protein coupled receptors trigger a cAMP-cascade in the cilia ...

Olfactory cilia (~60 μm long, 0.2 μm diameter) project from the apical knob of the single dendrite of olfactory sensory neurons (OSNs). Odorants binding to G-protein coupled receptors trigger a cAMP-cascade in the cilia ...