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Developing a collection of immobilized nucleoside phosphorylases for the preparation of nucleoside analogues: Enzymatic synthesis of arabinosyladenine and 2',3'-dideoxyinosine
(Wiley, 2013-02)
The use of nucleoside phosphorylases (NPs; EC 2.4.2.n) represents a convenient alternative to the chemical route for the synthesis of natural and modified nucleosides. We purified four recombinantly expressed nucleoside ...
A Chemoenzymatic Route To Prepare Acyclic Nucleoside Analogues
(Wiley VCH Verlag, 2016-02)
Acyclic nucleosides are potential antiviral and antitumor agents. In this work, their preparation through a novel chemoenzymatic procedure involving theN-alkylation of a nucleobase and subsequent aldol condensation catalyzed ...
Whole cell biocatalysts for the preparation of nucleosides and their derivatives
(Bentham Science Publishers, 2017-10)
Nucleosides constitute an extensive group of natural and chemically modified compounds that display a wide range of structures and activities. Different biocatalysts have been developed for their preparation, but the choice ...
Biocatalytic approaches applied to the synthesis of nucleoside prodrugs
(Pergamon-Elsevier Science Ltd, 2015-06)
Nucleosides are valuable bioactive molecules, which display antiviral and antitumour activities. Diverse types of prodrugs are designed to enhance their therapeutic efficacy, however this strategy faces the troublesome ...
6-methylmercaptopurine riboside, a thiopurine nucleoside with antiviral activity against canine distemper virus in vitro
(Biomed Central Ltd, 2017-06-26)
Background: Canine distemper (CD) is a widespread infectious disease that can severely impact a variety of species in the order Carnivora, as well as non-carnivore species such as non-human primates. Despite large-scale ...