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Role of the spinal cord heme oxygenase-carbon monoxide-cGMP pathway in the nociceptive response of rats
(ELSEVIER SCIENCE BV, 2008)
The aim of the present study was to investigate the role of the spinal cord heme oxygenase (HO)-carbon monoxide (CO)-soluble guanylate cyclase (sGC)-cGMP pathway in nociceptive response of rats to the formalin experimental ...
Pain modulated by Bothrops snake venoms: Mechanisms of nociceptive signaling and therapeutic perspectives
(2021-10-15)
Snake venoms are substances mostly composed by proteins and peptides with high biological activity. Local and systemic effects culminate in clinical manifestations induced by these substances. Pain is the most uncomfortable ...
The functional role of ascending nociceptive control in defensive behavior
(ELSEVIER SCIENCE BVAMSTERDAM, 2013-08-02)
Ascending nociceptive control is a novel spino-striato-rostral ventral medulla pain modulation pathway that mediates heterosegmental pain-induced analgesia, i.e., noxious stimulus-induced antinociception. In this study, ...
Analysis of the opioid-opioid combinations according to the nociceptive stimulus in mice
(2010)
The purpose of the present study was to characterize the antinociceptive effects of tramadol, fentanyl and morphine, when two of them were systemically combined in a 1:1 potency ratio, in the hot plate, the acetic acid ...
Trpa1, Substance P, Histamine And 5-hydroxytryptamine Interact In An Interdependent Way To Induce Nociception
(Springer Basel AGBasel, 2017)
Alterations in opioid inhibition cause widespread nociception but do not affect anxiety-like behavior in oral cancer mice
(2017-11-05)
Widespread pain and anxiety are commonly reported in cancer patients. We hypothesize that cancer is accompanied by attenuation of endogenous opioid-mediated inhibition, which subsequently causes widespread pain and anxiety. ...
Nociceptive modulation in rats by chemical stimulation of caudate, septum and medial forebrain bundle
(1980-01-01)
The effects of intracerebral microinjections of Thiopental (25 μg) and Metrazol (100 μg) on the defensive motor responses elicited by nociceptive electrical stimulation of the rat's tail were determined. Also, the action ...