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nfxB as a Novel Target for Analysis of Mutation Spectra in Pseudomonas aeruginosa
(Public Library Science, 2013-06-07)
nfxB encodes a negative regulator of the mexCD-oprJ genes for drug efflux in the opportunistic pathogen Pseudomonas aeruginosa. Inactivating mutations in this transcriptional regulator constitute one of the main mechanisms ...
Tellurium in organic synthesis: a new approach to trisubstituted gamma-butyrolactones with trans-trans relative stereochemistry. Total enantioselective synthesis of (-)-Blastmycinolactol, (+)-Blastmycinone, (-)-NFX-2, and (+)-Antimycinone
(PERGAMON-ELSEVIER SCIENCE LTD, 2010)
The total synthesis of (-)-Blastmycinolactol, (+)-Blastmycinone, (-)-NFX-2, and (+)-Antimycinone was accomplished in few steps in high yields and ee, starting from enantiomerically enriched (S)-Z-vinylic hydroxytellurides. ...
Tellurium in organic synthesis: a general approach to buteno- and butanolides
(Elsevier B.V., 2012-12-23)
The naturally occurring butanolides (-)-blastmycinolactol, (+)-blastmycinone, (-)-NFX-2, (+)-antimycinone as well as the four stereoisomers of the butenolide Acaterin were prepared in high enantiomeric purity using ...
Tellurium in organic synthesis: a general approach to buteno- and butanolides
(Elsevier B.V., 2012-10-07)
The naturally occurring butanolides (-)-blastmycinolactol, (+)-blastmycinone, (-)-NFX-2, (+)-anti-mycinone as well as the four stereoisomers of the butenolide Acaterin were prepared in high enantiomeric purity using ...
Tellurium in organic synthesis: a general approach to buteno- and butanolides
(PERGAMON-ELSEVIER SCIENCE LTDOXFORD, 2012)
The naturally occurring butanolides (-)-blastmycinolactol, (+)-blastmycinone, (-)-NFX-2, (+)-anti-mycinone as well as the four stereoisomers of the butenolide Acaterin were prepared in high enantiomeric purity using ...
Reactions of Nifurtimox with critical sulfhydryl-containing biomolecules: Their potential toxicology relevance
(John Wiley & Sons Ltd, 2004-05)
Nifurtimox (Nfx) is a drug used in the treatment of Chagas' disease, an endemic parasitic disease from Latin American countries. It produces undesirable side-effects in patients, frequently forcing the treatment to be ...
Alteraciones ultraestructurales en la mucosa del colon de ratas tratadas con nifurtimoxUltrastructural alterations in colonic mucosa of nifurtimox treated rats
(Medicina (Buenos Aires), 2001-12)
El nifurtimox (Nfx) es un fármaco empleado en el tratamiento del Mal de Chagas agudo que ha evidenciado en su uso clínico y en estudios experimentales efectos colaterales tóxicos que comprometen su empleo. Estos efectos ...
Metodología UV para la determinación de los antichagásicos Nifurtimox y Benznidazol en sangreUV methodology for determination of antichagasic drugs Nifurtimox and Benznidazol in bloodMetodologia UV para a determinação dos antichagásicos Nifurtimox e Benznidazol em sangue
(Federación Bioquímica de la Provincia Buenos Aires, 2011-09)
El Mal de Chagas es una enfermedad parasitaria endémica en América del Sur y Central. Existen dos fármacos disponibles para el tratamiento médico de la enfermedad, el Nifurtimox (Nfx) y el Benznidazol (Bz). No existen ...
Tratamiento de la enfermedad de Chagas crónica en Chile. efectos adversos de nifurtimox
(UNIVERSIDAD DE CHILE, 2012)
Hoy en día, los únicos fármacos aceptados para el tratamiento de la enfermedad de Chagas, son nifurtimox (NFX) y benznidazol (BNZ). Con el fin de conocer los efectos adversos de NFX, se realizó un estudio en 60 pacientes ...
Nifurtimox versus benznidazole or placebo for asymptomatic Trypanosoma cruzi infection (Equivalence of Usual Interventions for Trypanosomiasis - EQUITY): Study protocol for a randomised controlled trial
Background: Either benznidazole (BZN) or nifurtimox (NFX) is recommended as equivalent to treat Trypanosoma cruzi infection. Nonetheless, supportive data from randomised trials is limited to individuals treated with BZN ...