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Modern drug discovery technologies: opportunities and challenges in lead discovery
(Bentham ScienceBussum, 2011-12)
The identification of promising hits and the generation of high quality leads are crucial steps in the early stages of drug discovery projects. The definition and assessment of both chemical and biological space have ...
Current advances in antitubercular drug discovery: potent prototypes and new targets
(Bentham Science Publishers, 2015)
Tuberculosis (TB) is an infectious disease caused by bacterium of the Mycobacterium genus, mainly by Mycobacterium tuberculosis (MTB). The World Health Organization aims to substantially reduce the number of cases in the ...
Advances in drug discovery of new antitubercular multidrug-resistant compounds
(2017-06-01)
Tuberculosis (TB), a disease caused mainly by the Mycobacterium tuberculosis (Mtb), is according to the World Health Organization (WHO) the infectious disease responsible for the highest number of deaths worldwide. The ...
Recent advances in the discovery of small molecules targeting glioblastoma
(2019-02-15)
Glioblastoma (GBM) is one of the most common central nervous system cancers. It is characterized as a fast-growing tumor that arises from multiple cell types with neural stem-cell-like properties. Additionally, GBM tumors ...
Discovery by Serendipity: a new context for an old riddle
(2015-02-09)
In the last years there has been a great improvement in the
development of computational methods for combinatorial chemistry applied to
drug discovery. This approach to drug discovery is sometimes called a “rational
way” ...
Antimalarial drug discovery: screening of Brazilian medicinal plants and purified compound
(Informa Health Care, 2014)
Viruses, definitions and reality
(Universidad de Costa Rica, 2011)
Price Discovery in Brazilian FX Markets
(Sociedade Brasileira de Econometria, 2015)