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A study of bio-hybrid silsesquioxane/yeast: Biosorption and neuronal toxicity of lead
(2017-12-20)
Lead is a heavy metal of high impact for the environment as well as for human health, being cause of several diseases. Considering the importance of obtaining an effective treatment for lead removal, a new hybrid material ...
Amino acid analog toxicity in primary rat neuronal and astrocyte cultures: Implications for protein misfolding and TDP-43 regulation
(Wiley, 2011-09)
Amino acid analogs promote translational errors that result in aberrant protein synthesis, and have been used to understand the effects of protein misfolding in a variety of physiological and pathological settings. TDP-43 ...
Damaging effects of BMAA on retina neurons and Müller glial cells
(Elsevier Science Ltd, 2020-11-01)
B–N-methylamino-L-alanine (BMAA), a cyanotoxin produced by most cyanobacteria, has been proposed to cause long term damages leading to neurodegenerative diseases, including Amyotrophic Lateral Sclerosis/Parkinsonism Dementia ...
GABAA receptor and cell membrane potential as functional endpoints in cultured neurons to evaluate chemicals for human acute toxicity
(Pergamon-Elsevier Science Ltd, 2010-02)
Toxicity risk assessment for chemical-induced human health hazards relies mainly on data obtained from animal experimentation, human studies and epidemiology. In vitro testing for acute toxicity based on cytotoxicity assays ...
Neurotoxicity of the pesticide rotenone on neuronal polarization: A mechanistic approach
(Shenyang Editorial Dept Neural Regeneration Res, 2019-05)
Neurons are the most extensive and polarized cells that display a unique single long axon and multiple dendrites, which are compartments exhibiting structural and functional differences. Polarity occurs early in neuronal ...
Studies with neuronal cells: From basic studies of mechanisms of neurotoxicity to the prediction of chemical toxicity
(Pergamon-Elsevier Science Ltd, 2008-08)
Neurotoxicology considers that chemicals perturb neurological functions by interfering with the structure or function of neural pathways, circuits and systems. Using in vitro methods for neurotoxicity studies should include ...