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CCR5-Dependent Homing of T Regulatory Cells to the Tumor Microenvironment Contributes to Skin Squamous Cell Carcinoma Development
(Amer Assoc Cancer Research, 2017-12-01)
Squamous cell carcinoma (SCC) is one of the most common human cancers worldwide. Recent studies show that regulatory T cells (Treg) have a critical role in the modulation of an antitumor immune response, and consequently ...
Frequency of polymorphisms of genes coding for HIV-1 co-receptors CCR5 and CCR2 in a Brazilian population
(Brazilian Society of Infectious Diseases, 2003-08-01)
Entry of human immunodeficiency type 1 virus (HIV-1) into target cells requires both CD4and one of the chemokine receptors. Viruses predominantly use one, or occasionally both, of the major co-receptors CCR5 and CXCR4, ...
Better CD4+T Cell Recovery in Brazilian HIV-Infected Individuals Under HAART Due to Cumulative Carriage of SDF-1-3`A, CCR2-V64I, CCR5-D32 and CCR5-Promoter 59029A/G Polymorphisms
(BENTHAM SCIENCE PUBL LTD, 2008)
Polymorphisms of chemokines and chemokine-receptors genes have been shown to influence the rate of progression to AIDS; however, their influence on response to HAART remains unclear. We investigated the frequency of the ...
CCR5 genotype and plasma ß-chemokine concentration of Brazilian HIV-infected individuals
(Associação Brasileira de Divulgação Científica (ABRADIC), 2002-11-01)
The 32-bp deletion in the HIV-1 co-receptor CCR5 confers a high degree of resistance to HIV-1 infection in homozygous individuals for the deleted allele and partial protection against HIV-1 during disease progression in ...
CCR5 genotype and plasma ß-chemokine concentration of Brazilian HIV-infected individuals
(Associação Brasileira de Divulgação Científica (ABRADIC), 2002-11-01)
The 32-bp deletion in the HIV-1 co-receptor CCR5 confers a high degree of resistance to HIV-1 infection in homozygous individuals for the deleted allele and partial protection against HIV-1 during disease progression in ...
Distribution of the CCR5delta32 allele (gene variant CCR5) in Rondonia, Western Amazonian region, Brazil
(SOC BRASIL GENETICARIBEIRAO PRET, 2012)
Since around 1723, on the occasion of its initial colonization by Europeans, Rondonia has received successive waves of immigrants. This has been further swelled by individuals from northeastern Brazil, who began entering ...
CCR5 Down-regulates Osteoclast Function in Orthodontic Tooth Movement
(SAGE PUBLICATIONS INC, 2009)
During orthodontic tooth movement, there is local production of chemokines and an influx of leukocytes into the periodontium. CCL5 plays an important role in osteoclast recruitment and activation. This study aimed to ...
CCR5 chemokine receptor gene polymorphisms in ocular toxoplasmosis
(2018-02-01)
C–C chemokine receptor type 5 (CCR5) is a chemokine receptor that influences the immune response to infectious and parasitic diseases. This study aimed to determine whether the CCR5Δ32 and CCR5 59029 A/G polymorphisms are ...
Essential Role of CCR2 in Neutrophil Tissue Infiltration and Multiple Organ Dysfunction in Sepsis
(AMER THORACIC SOC, 2011)
Rationale Sepsis is defined as a systemic inflammatory response to infection, which in its severe form is associated with multiple organ dysfunction syndrome (MODS). The precise mechanisms by Which MODS develops remain ...
CCR5 Mediates Pro-osteoclastic and Osteoclastogenic Leukocyte Chemoattraction
(SAGE PUBLICATIONS INC, 2011)
Periodontal disease (PD) progression involves the selective leukocyte infiltration into periodontium, supposedly mediated by the chemokine/chemokine receptor system. In this study, we investigated the role of chemokine ...