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UFR2709, a nicotinic acetylcholine receptor antagonist, decreases ethanol intake in alcohol-preferring rats
(Frontiers Media S.A., 2019)
The position of the double bond in monounsaturated free fatty acids is essential for the inhibition of the nicotinic acetylcholine receptor
(Elsevier B.V., 2012)
Abstract: Free fatty acids (FFAs) are non-competitive antagonists of the nicotinic acetylcholine receptor (AChR). Their site of action is supposedly located at the lipid-AChR interface. To elucidate the mechanism involved ...
Antagonistas de los receptores de acetilcolina nicotínicos α4β2 reducen el consumo de etanol en el modelo de rata bebedora UChB.Antagonists of nicotinic acetylcholine receptors α4β2 reduce ethanol consumption in the high-drinking model UChB rat.
(2019)
Introducción y propuesta: La literatura acumulada sugiere que los receptores de acetilcolina nicotínicos (nAChRs) de subtipo α4β2 pueden ser considerados como blancos farmacológicos para el tratamiento de abuso de alcohol. ...
Nicotinic α4 receptor-mediated cholinergic influences on food intake and activity patterns in hypothalamic circuits
(Public Library of Science, 2015)
Abstract: Nicotinic acetylcholine receptors (nAChRs) play an important role in regulating appetite and have been shown to do so by influencing neural activity in the hypothalamus. To shed light on the hypothalamic circuits ...
VdTX-1, a reversible nicotinic receptor antagonist isolated from venom of the spider Vitalius dubius (Theraphosidae)
(Pergamon-elsevier Science LtdOxfordInglaterra, 2013)
Methylpiperidinium Iodides as novel antagonists for alpha 7 nicotinic acetylcholine receptors
(Frontiers Media, 2018)
The alpha 7 nicotinic acetylcholine receptor (nAChR) is expressed in neuronal and non-neuronal cells and is involved in several physiopathological processes, and is thus an important drug target. We have designed and ...
Síntese e avaliação biológica de compostos da série LINS01 como agentes pró-cognitivos: uma abordagem multialvo
(Universidade Federal de São Paulo, 2021-07-01)
A maioria das desordens neurológicas estão associadas com certo declínio cognitivo. Os mecanismos que regem os processos de memória e aprendizado são complexos e comumente explorados na busca por alvos para uma melhor ...
Búsqueda racional de alcaloides isoquinolínicos del género Zanthoxylum (Rutaceae) como posibles agentes multifuncionales para el tratamiento del Alzheimer
(Bogotá - Ciencias - Doctorado en Ciencias - QuímicaDepartamento de QuímicaUniversidad Nacional de Colombia - Sede Bogotá, 2020-07-22)
Los trastornos neurodegenerativos multifactoriales, como la enfermedad de Alzheimer (EA), son un problema creciente de salud pública mundial debido al aumento de su incidencia y la baja efectividad de los tratamientos ...