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Analysis of molecular markers as predictive factors of lymph node involvement in breast carcinoma
(Spandidos Publ Ltd, 2017-01-01)
Nodal status is the most significant independent prognostic factor in breast cancer. Identification of molecular markers would allow stratification of patients who require surgical assessment of lymph nodes from the large ...
Suppression of Age-Related Salivary Gland Autoimmunity by Glycosylation-Dependent galectin-1-driven Immune Inhibitory Circuits
(National Academy of Sciences, 2020-03)
Aging elicits quantitative and qualitative changes in different immune components, leading to disruption of tolerogenic circuits and development of autoimmune disorders. Galectin-1 (Gal1), an endogenous glycan-binding ...
Spatiotemporal regulation of galectin-1-induced T-cell death in lamina propria from Crohn’s disease and ulcerative colitis patients
(Springer, 2021-06)
Inflammatory bowel disease (IBD), including Crohn’s disease (CD) and ulcerative colitis (UC), is characterized by chronic, relapsing intestinal inflammation. Galectin-1 (Gal-1) is an endogenous lectin with key pro-resolving ...
Control of intestinal inflammation by glycosylation-dependent lectin-driven immunoregulatory circuits
(Science Advances is the American Association for the Advancement of Science, 2021-06)
Diverse immunoregulatory circuits operate to preserve intestinal homeostasis and prevent inflammation. Galectin-1 (Gal1), a β-galactoside-binding protein, promotes homeostasis by reprogramming innate and adaptive immunity. ...
Genetic Modification of Glycosylation Pathway in Epithelial Cells of Mammary Gland".Modificación Genética de la Ruta de Glicosilación en Células Epiteliales de Glándula Mamaria."
(2021)
Currently there are several systems for therapeutic recombinant proteins expression, and their choice will depend on the type of protein that needs to be expressed, since the system must provide correct post-translational ...
Predominant and novel de novo variants in 29 individuals with ALG13 deficiency: Clinical description, biomarker status, biochemical analysis, and treatment suggestions
(Springer, 2020-11)
Asparagine-linked glycosylation 13 homolog (ALG13) encodes a nonredundant, highly conserved, X-linked uridine diphosphate (UDP)-N-acetylglucosaminyltransferase required for the synthesis of lipid linked oligosaccharide ...
Avaliação de glicosilação e beta1-integrina em carcinomas mamários: valor diagnóstico e prognóstico na progressão tumoral e status linfonodal
(Universidade Federal de PernambucoUFPEBrasilPrograma de Pos Graduacao em Inovacao Terapeutica, 2016)