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Effects of chloroquine pretreatment on lethal dose of morphine and on morphine metabolism in rats
The previous administration of chloroquine to normal rats resulted in a significant increase in the lethal dose of morphine and in a higher amount of conjugated morphine in the liver. No differences were found on normorphine ...
Antinociceptive effects of morphine, fentanyl, tramadol and their combination, in morphine-tolerant mice
(Elsevier Inc., 2010)
The development of morphine-tolerance after chronic administration, reduces analgesic efficacy and is a significant clinical problem in some patients; may be managed clinically by increasing the doses of morphine and/or ...
Synergy between the antinociceptive effects of morphine and NSAIDs
The intraperitoneal administration of morphine, diclofenac, ketoprofen, meloxicam, metamizol, paracetamol and piroxicam induced dose-dependent antinociception in mice tested with the acetic acid writhing test. The ...
Morphine at inflammatory experimental pain: A review
Pain is a complex entity that can be described in several dimensions, such as, acute pain and chronic pain, characterized by its duration. After the tissue injury, the activation of the sensory nervous tissue occurs from ...
Morphine and clinical outcomes in patients with ST segment elevation myocardial infarction treated with fibrinolytic and antiplatelet therapy: Insights from the TREAT trial
Background: Morphine is commonly used to relieve pain, anxiety and dyspnea in STEMI but it lowers blood pressure and delays the activity of oral antiplatelet agents. The impact of morphine on clinical outcomes remains ...
Influence of anti-inflammatory drugs on the electroencephalographic effect of morphine in rabbits
The influence of sodium salicylate, di- pyrone and indomethacin on the electroencephalographic effect of morphine was quantitatively studied in rabbits bearing chronically implanted electrodes. Salicylate alone produced a ...
A Novel Morphine Drinking Model of Opioid Dependence in Rats
Abstract: An animal model of voluntary oral morphine consumption would allow for a pre-clinical evaluation of new treatments aimed at reducing opioid intake in humans. However, the main limitation of oral morphine consumption ...
Analgesic comparison of systemic lidocaine, morphine or lidocaine plus morphine infusion in dogs undergoing fracture repair1
(Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia, 2014-04)
Effect of human mesenchymal stem cell secretome administration on morphine self-administration and relapse in two animal models of opioid dependence
The present study investigates the possible therapeutic effects of human mesenchymal stem cell-derived secretome on morphine dependence and relapse. This was studied in a new model of chronic voluntary morphine intake in ...
A novel morphine drinking model of opioid dependence in rats
An animal model of voluntary oral morphine consumption would allow for a pre-clinical evaluation of new treatments aimed at reducing opioid intake in humans. However, the main limitation of oral morphine consumption in ...