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Effect of ganglioside (GM1) on memory in senescent rats
(Elsevier B.V., 1996-07-01)
Monosialoganglioside GM1 (GM1) has been found to alleviate genetic and lesion-induced memory deficits. The purpose of this study was to investigate the effects of 7-day treatment with GM1 (50 mg/kg IF) on acquisition and ...
Monosialoganglioside (GM(1)) attenuates the behavioural effects of longterm haloperidol administration in supersensitive rats
(Elsevier B.V., 2004-03-01)
In the present study we investigated the effects of co-administration of GM(1) (15.0 mg/kg, twice daily, for 30 days) and haloperidol (1.0 mg/kg, twice daily, for 30 days), as well as the effects of a 5-day treatment with ...
Effects of monosialoganglioside on a new model of tardive dyskinesia
(Elsevier B.V., 1997-10-01)
1- the effects of monosialoganglioside GM(1) were studied on a new model of tardive dyskinesia, i.e., the frequency of spontaneous tongue protrusions in rats repeatedly treated with reserpine.2- Rats were co-treated with ...
Antibodies can be spontaneously loaded onto monosialoganglioside micelles containing oncological drugs
(Longdom, 2019-05)
Recently, we demonstrated that GM1 micelles transport paclitaxel and doxorubicin with high efficiency. Whenthis GM1-drugs complex is incubated with whole serum, albumin was the only one protein that binds spontaneouslyto ...
Efeito do monossialogangliosídeo GM1 sobre as alterações comportamentais, euroquímicas e eletrográficas induzidas pelo ácido glutárico e nas defesas antioxidantes no SNC de ratos
(Universidade Federal de Santa MariaBRBioquímicaUFSMPrograma de Pós-Graduação em Ciências Biológicas: Bioquímica Toxicológica, 2006-05-12)
Monosialoganglioside (GM1) is a component of most cell membranes and is thought to play a role in development, recognition and cellular differentiation. Furthermore, GM1 is a neuroprotective agent that has been reported ...
Monosialoganglioside GM1 reduces toxicity of Ptx and increase anti-metastasic effect in a murine mammary cancer model
(Nature Research, 2020-12)
Having demonstrated the ability of monosialoganglioside GM1 micelles as oncology drug transporter, this work focuses on evaluating its application in an in vivo system, studying the toxicity and antitumoral effect of GM1-Ptx ...
GM1 ganglioside attenuates convulsions and thiobarbituric acid reactive substances production induced by the intrastriatal injection of methylmalonic acid
(Elsevier B.V., 2003-04-01)
The effects of the administration of monosialoganglioside (GM1) on methylmalonic acid (MMA)-induced convulsions, production of thiobarbituric acid reactive substances (TBARS) and on the striatal content of ascorbic acid ...
Testosterone-loaded GM1 micelles targeted to the intracellular androgen receptor for the specific induction of genomic androgen signaling
(Elsevier Science, 2020-12)
Androgens play a central role in homeostatic and pathological processes of the prostate gland. At the cellular level, testosterone activates both the genomic signaling pathway, through the intracellular androgen receptor ...
Role of cell surface GM3 ganglioside and sialic acid in the antitumor activity of a GM3-based vaccine in the murine B16 melanoma model
(Springer, 2002-12)
Purpose: To examine the role of GM3 monosialoganglioside and sialic acid in the antitumor activity of a vaccine based on GM3, hydrophobically conjugated with the outer-membrane-protein complex from Neisseria meningitidis ...
LDL-conjugated to GM1 micelles incorporating anticancer drugs to improve tumor cell uptake
(Mashhad University of Medical Sciences, 2021-03)
Objective(s): The role of lipoproteins (LDL) as active molecules with preferential tumor interaction, but limited drug delivery capacity, has been previously reported. On the other hand, in a previous report, we demonstrated ...