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Mfn2 downregulation in excitotoxicity causes mitochondrial dysfunction and delayed neuronal death
(Wiley-VCH Verlag, 2014)
Inhibition of the proteasome preserves Mitofusin-2 and mitochondrial integrity, protecting cardiomyocytes during ischemia-reperfusion injury
(Elsevier, 2020)
Cardiomyocyte loss is the main cause of myocardial dysfunction following an ischemia-reperfusion (IR) injury. Mitochondrial dysfunction and altered mitochondrial network dynamics play central roles in cardiomyocyte death. ...
Inhibition of chymotrypsin-like activity of the proteasome by ixazomib prevents mitochondrial dysfunction during myocardial ischemia
(Public Library Science, 2020)
The heart is critically dependent on mitochondrial respiration for energy supply. Ischemia decreases oxygen availability, with catastrophic consequences for cellular energy systems. After a few minutes of ischemia, the ...
Toxicidade do mercúrio em ratas virgens, gestantes e lactantes: efeito protetor do zinco e da N-acetilcisteína
(Universidade Federal de Santa MariaBRBioquímicaUFSMPrograma de Pós-Graduação em Ciências Biológicas: Bioquímica Toxicológica, 2016-07-15)
Mercury (Hg) is a divalent metal found liquid at room temperature without biological functions and anthropogenically released in industrial, agricultural activities and burning of fossil fuels. Toxic effects caused by ...
Changes in mitochondrial dynamics during ceramide-induced cardiomyocyte early apoptosis
(ELSEVIER SCIENCE BV, 2008-01-15)
Aims In cells, mitochondria are organized as a network of interconnected organelles that fluctuate between fission and fusion events (mitochondrial dynamics). This process is associated with cell death. We investigated ...
Efeitos da fototerapia em marcadores inflamatórios, na função mitocondrial e no estresse oxidativo em roedores com diabetes induzida
(Universidade Federal de São CarlosUFSCarPrograma de Pós-Graduação em Fisioterapia - PPGFtCâmpus São Carlos, 2016-05-09)
Tissue repair in diabetic patients is hampered by several factors, including secretion of
insulin deficiency that leads to hyperglycemia and production of free radicals.
Mitochondrial dysfunction has been identified as ...
Efecto cardioprotector de N-Acetilcisteína en el daño producido por isquemia, sobre el contenido de Mitofusina 2, en corazón aislado de rata
(Universidad de Chile, 2016)
El infarto agudo de miocardio es la principal causa de muerte por enfermedad isquémica coronaria en Chile. Durante isquemia predomina el metabolismo anaeróbico, disminuye la síntesis de ATP y se generan especies reactivas ...
Regulación del metabolismo energético cardiaco por insulina y su relación con la fusión y fisión mitocondrial
(Universidad de Chile, 2011)
Las mitocondrias corresponden a una red organelar altamente dinámica e
interconectada, mantenida por eventos frecuentes de fisión y fusión. A través de
estos procesos, las mitocondrias adoptan diferentes formas en respuesta ...
Regulación de la dinámica y metabolismo mitocondrial por incretina GLP-1 en células de la línea A7r5
(Universidad de Chile, 2014)
El péptido similar a glucagón-1 (GLP-1) es una incretina secretada por las células intestinales. Su acción clásica es regular la respuesta secretoria de insulina por el páncreas. Sin embargo, recientemente se ha descrito ...