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Mitochondrial translation in health and disease
(SciResDelaware, 2013)
Mitochondrial disorders have become the most common cause of inborn errors of metabolism. Impairments in mitochondrial protein synthesis are one of the causes of these diseases, which are clinically and genetically ...
Fast-twitch glycolytic skeletal muscle is predisposed to age-induced impairments in mitochondrial function
(Gerontological Society of America, 2013)
The etiology of mammalian senescence is suggested to involve the progressive impairment of mitochondrial function; however, direct observations of age-induced alterations in actual respiratory chain function are lacking. ...
MITOCHONDRIAL RESPIRATORY CHAIN AND CREATINE KINASE ACTIVITIES IN mdx MOUSE BRAIN
(JOHN WILEY & SONS INC, 2010)
In this study we investigated energy metabolism in the mdx mouse brain. To this end, prefrontal cortex, cerebellum, hippocampus, striatum, and cortex were analyzed. There was a decrease in Complex I but not in Complex 11 ...
Leigh-like syndrome with the T8993G mutation in the mitochondrial ATPase 6 gene: long-term follow-up discloses a slowly progressive course
(ELSEVIER SCIENCE BV, 2009)
We describe the long-term clinical outcome of a patient with Leigh-like syndrome presenting as an early onset encephalopathy and peripheral neuropathy caused by the T8993G mutation in the mitochondrial DNA (mtDNA). Clinical ...
NO control of mitochondrial function in normal and transformed cells
(Elsevier Science Bv, 2017)
Nitric oxide (NO) is a signaling molecule with multiple facets and involved in numerous pathological process, including cancer. Among the different pathways where NO has a functionally relevant participation, is the control ...
Mitochondrial dysfunction and therapeutic approaches in respiratory and limb muscles of cancer cachectic mice
(Wiley, 2013-09)
Abnormalities in mitochondrial content, morphology, and function were reported in several muscle wasting conditions. We specifically explored whether experimental cancer-induced cachexia may alter mitochondrial respiratory ...
A Chemiresistor Sensor Based on Azo-Polymer and Graphene for Real-Time Monitoring of Mitochondrial Oxygen Consumption
(2019-01-25)
In the present study, a chemiresistor sensor based on a poly(Bismarck Brown Y)-reduced graphene oxide nanocomposite was developed to analyze the respiratory capacity of the constituent complexes of the electron transport ...
Mitochondrial Alterations in Nonalcoholic Fatty Liver Disease. Pediatric Case Description of Three Submitted Sequential Biopsies
(Medical Univ PressCluj-napocaRoménia, 2009)
Determinants of anti-cancer effect of mitochondrial electron transport chain inhibitors: Bioenergetic profile and metabolic flexibility of cancer cells
(Bentham Science Publishers B.V., 2016)
© 2016 Bentham Science Publishers. Recent evidence highlights that energy requirements of cancer cells vary greatly from normal cells and they exhibit different metabolic phenotypes with variable participation of both ...
Neonatal mitochondrial encephaloneuromyopathy due to a defect of mitochondrial protein synthesis
(ELSEVIER SCIENCE BV, 2008)
Mitochondrial diseases are clinically and genetically heterogeneous disorders due to primary mutations in mitochondrial DNA (mtDNA) or nuclear DNA (nDNA). We studied a male infant with severe congenital encephalopathy, ...