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Split-dose administration of thiopurine drugs: a novel and effective strategy for managing preferential 6-MMP metabolism
(WILEY-BLACKWELL, 2012)
Background Mercaptopurine and azathioprine (AZA) are efficacious in treating IBD. 6-tioguanine (6-TGN) levels correlate with therapeutic efficacy, whereas high 6-methylmercaptopurine (6-MMP) levels are associated with ...
Toxicity evaluation of 6-mercaptopurine-Chitosan nanoparticles in rats
(2020-01-01)
Background: The 6-mercaptopurine (6-MP) is an effective immunosuppressant and anti-cancer drug. However, the usage of 6-MP is limited due to its well-known side effects, such as myelotoxicity and hepato-renal toxicity. To ...
6-Mercaptopurine Self-Assembled Monolayers on Gold (001)-Hex: Revealing the Fate of Gold Adatoms
(American Chemical Society, 2017-04)
Thiol molecules adsorbed on gold became a model system for molecular self-assembly on metal substrates long ago. In most cases the strong molecule-gold interaction is able to restructure the substrate, resulting in vacancy ...
Electronic Structure of a Self-Assembled Monolayer with Two Surface Anchors: 6-Mercaptopurine on Au(111)
(American Chemical Society, 2018-05)
The electronic structure of aromatic and aliphatic thiols on Au(111) has been extensively studied in relation to possible applications in molecular electronics. In this work, the effect on the electronic structure of an ...
6-Mercaptopurine complexes with silver and gold ions: Anti-tuberculosis and anti-cancer activities
(Elsevier France-editions Scientifiques Medicales Elsevier, 2011-08-01)
Synthesis, characterization and biological studies of silver and gold complexes with 6-mercaptopurine (H2MP) are described. The Ag(I) and Au(I) complexes with HMP-, AgHMP and AuIHMP, were obtained by mixing an acidified ...
6-Mercaptopurine complexes with silver and gold ions: Anti-tuberculosis and anti-cancer activities
(Elsevier France-editions Scientifiques Medicales Elsevier, 2011-08-01)
Synthesis, characterization and biological studies of silver and gold complexes with 6-mercaptopurine (H2MP) are described. The Ag(I) and Au(I) complexes with HMP-, AgHMP and AuIHMP, were obtained by mixing an acidified ...
6-Mercaptopurine complexes with silver and gold ions: Anti-tuberculosis and anti-cancer activities
(Elsevier France-editions Scientifiques Medicales Elsevier, 2014)