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Repeated divergent selection on pigmentation genes in a rapid finch radiation
(American Association for the Advancement of Science, 2017-05)
Instances of recent and rapid speciation are suitable for associating phenotypes with their causal genotypes, especially if gene flow homogenizes areas of the genome that are not under divergent selection. We study a rapid ...
Standardization of organoid culture for evaluation of melanogenesis induced by UVB, UVA and visible light
(Elsevier B.V., 2020-01-01)
Background: Organoid cultures are primary cultures that maintain architectural characteristics and the relationships between cells, as well as the extracellular matrix. They are alternatives for pathophysiological or ...
Gene and protein expression of oestrogen-beta and progesterone receptors in facial melasma and adjacent healthy skin in women
(Wiley-Blackwell, 2015-04-01)
SynopsisObjectiveCompare gene and protein expression for oestrogen receptor- (ER-) and progesterone receptor (PR) in facial melasma and adjacent healthy skin.MethodsA cross-sectional study including 42 women with facial ...
Reprogramming human A375 amelanotic melanoma cells by catalase overexpression: Upregulation of antioxidant genes correlates with regression of melanoma malignancy and with malignant progression when downregulated
(Karger, 2016-05)
Reactive oxygen species (ROS) are implicated in tumor transformation. The antioxidant system (AOS) protects cells from ROS damage. However, it is also hijacked by cancers cells to proliferate within the tumor. Thus, ...
Characterization and expression analysis of KIT and MITF ‐M genes in llamas and their relation to white coat color
(Wiley Blackwell Publishing, Inc, 2019-02)
The llama (Lama glama) is a fiber-producing species that presents a wide range of coat colors, among which white is one of the most important for the textile industry. However, there is little information about the molecular ...
BAP1 regulates epigenetic switch from pluripotency to differentiation in developmental lineages giving rise to BAP1-mutant cancers
(American Association for the Advancement of Science, 2019-09)
The BAP1 tumor suppressor is mutated in many human cancers such as uveal melanoma, leading to poor patient outcome. It remains unclear how BAP1 functions in normal biology or how its loss promotes cancer progression. Here, ...
Padronização de cultura organóide cutânea e avaliação da resposta melanogênica no melasma ao UVB, UVA e luz visível.
(Universidade Estadual Paulista (Unesp), 2019-09-26)
FUNDAMENTOS: Melasma é hipermelanose crônica, focal, adquirida decorrente de patogênese não totalmente compreendida, resultado da alteração funcional e arquitetural dos melanócitos. A predisposição genética, aspectos ...