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Sequence and function of lysosomal and digestive cathepsin D-like proteinases of Musca domestica midgut
(PERGAMON-ELSEVIER SCIENCE LTD, 2009)
Musca domestica larvae display in anterior and middle midgut contents, a proteolytic activity with pH optimum of 3.0-3.5 and kinetic properties like cathepsin D. Three cDNAs coding for preprocathepsin D-like proteinases ...
Recombinant human cathepsin X is a carboxymonopeptidase only: a comparison with cathepsins B and L
(Walter de Gruyter & Co, 2005-11-01)
The S-1 and S-2 subsite specificity of recombinant human cathepsins X was studied using fluorescence resonance energy transfer (FRET) peptides with the general sequences Abz-Phe-Xaa-Lys(Dnp)-OH and Abz-XaaArg-Lys(Dnp)-OH, ...
Localization of Cathepsins D and B at the Maternal-Fetal Interface and the Invasiveness of the Trophoblast during the Postimplantation Period in the Mouse
(KARGER, 2011)
A survey of existing data suggests that trophoblast cells produce factors involved in extracellular matrix degradation. In this study, we correlated the expression of cathepsins D and B in the murine ectoplacental cone ...
Cathepsin X binds to cell surface heparan sulfate proteoglycans
(Elsevier B.V., 2005-04-15)
Glycosaminoglycans have been shown to be important regulators of activity of several papain-like cathepsins. Binding of glycosaminoglycans to cathepsins thus directly affects catalytic activity, stability or the rate of ...
Purification and partial characterization of cathepsin D from porcine (Sus scrofa) liver using affinity chromatography
(Academic Press Aust, 1998-07-01)
Cathepsin D, a lysosomal aspartic protease, has been purified from porcine liver using a combination of pepstatin-A agarose and Affi-Gel Blue affinity chromatography, followed by size-exclusion chromatography. The purified ...
Interplay between lysosomal, mitochondrial and death receptor pathways during manganese-induced apoptosis in glial cells
(Springer, 2017-09)
Manganese (Mn) is an essential trace metal which plays a critical role in brain physiology by acting as a cofactor for several enzymes. However, upon overexposure, Mn preferentially accumulates within the basal ganglia ...
Streptozotocin-induced diabetes mellitus affects lysosomal enzymes in rat liver
(Associação Brasileira de Divulgação Científica, 2014-06-01)
It has been previously shown that dextran sulfate administered to diabetic rats accumulates in the liver and kidney, and this could be due to a malfunction of the lysosomal digestive pathway. The aim of the present study ...
Endosomes and lysosomes are involved in early steps of Tl(III)-mediated apoptosis in rat pheochromocytoma (PC12) cells
(Springer, 2012-11)
The mechanisms that mediate thallium (Tl) toxicity are still not completely understood. The exposure of rat pheochromocytoma (PC12) cells to Tl(I) or Tl(III) activates both mitochondrial (Tl(I) and Tl(III)) and extrinsic ...