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A mechanistic approach for the optimization of loperamide loaded nanocarriers characterization: Diafiltration and mathematical modeling advantages
(Elsevier B.V., 2018)
© 2018 Elsevier B.V. Oral bioavailability of loperamide is restricted by its limited absorption in the gastrointestinal tract due to its poor aqueous solubility and its P-glycoprotein (Pgp) substrate characteristic. In ...
Loperamide mobilizes intracellular Ca 2+ stores in insulin-secreting HIT-T15 cells
(2003)
1 We have investigated the effects of loperamide on intracellular Ca2+ stores and membrane K+
channels in insulin-secreting hamster insulinoma (HIT-T15) cells.
2 In cell-attached patch-clamp mode, loperamide (3 – 250 mM) ...
Poloxamer 188-Coated Ammonium Methacrylate Copolymer Nanocarriers Enhance Loperamide Permeability across Pgp-Expressing Epithelia
(American Chemical Society, 2021-02)
Loperamide is a μ-opioid agonist with poor gastrointestinal absorption, mainly because of its modest aqueous solubility and being a P-glycoprotein (Pgp) efflux substrate. Nevertheless, studies associated with therapeutic ...
Efecto antidiarreico del extracto hidroalcoholico de la raíz de eleutherine bulbosa (yahuar piri piri) en ratones
(2018-11-06)
El objetivo fue determinar en la medida que el extracto hidroalcohólico de la raíz de Eleutherine bulbosa (yahuar piri piri) tiene efecto antidiarreico en ratones. La metodología empleada fue de tipo experimental, prospectivo ...
Refining the intestinal motility test in mice to reduce animal stress
(2003-12-01)
A new protocol using 3-h fast animal for intestinal motility test was developed in our laboratory aiming the 3R's concept to reduce the stress of animals. Our results may aid in formulating recommendations that can be ...
Refining the intestinal motility test in mice to reduce animal stress
(2003-12-01)
A new protocol using 3-h fast animal for intestinal motility test was developed in our laboratory aiming the 3R's concept to reduce the stress of animals. Our results may aid in formulating recommendations that can be ...
A mechanistic approach for the optimization of loperamide loaded nanocarriers characterization: Diafiltration and mathematical modeling advantages
(2018)
Oral bioavailability of loperamide is restricted by its limited absorption in the gastrointestinal tract due to its poor aqueous solubility and its P-glycoprotein (Pgp) substrate characteristic. In addition, ammonium ...
A mechanistic approach for the optimization of loperamide loaded nanocarriers characterization: Diafiltration and mathematical modeling advantages
(2018)
Oral bioavailability of loperamide is restricted by its limited absorption in the gastrointestinal tract due to its poor aqueous solubility and its P-glycoprotein (Pgp) substrate characteristic. In addition, ammonium ...
A mechanistic approach for the optimization of loperamide loaded nanocarriers characterization: Diafiltration and mathematical modeling advantages
(ELSEVIER SCIENCE BV, 2018)
Oral bioavailability of loperamide is restricted by its limited absorption in the gastrointestinal tract due to its poor aqueous solubility and its P-glycoprotein (Pgp) substrate characteristic. In addition, ammonium ...