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Utp25p, a nucleolar Saccharomyces cerevisiae protein, interacts with U3 snoRNP subunits and affects processing of the 35S pre-rRNA
(WILEY-BLACKWELL, 2010)
In eukaryotes, pre-rRNA processing depends on a large number of nonribosomal trans-acting factors that form intriguingly organized complexes. Two intermediate complexes, pre-40S and pre-60S, are formed at the early stages ...
Crystallographic characterization of the ribosomal binding site and molecular mechanism of action of Hygromycin A.
(Oxford University Press, 2015-11-16)
Hygromycin A (HygA) binds to the large ribosomal subunit and inhibits its peptidyl transferase (PT) activity. The presented structural and biochemical data indicate that HygA does not interfere with the initial binding of ...
Dissection of the 16S rRNA binding site for ribosomal protein S4
(Elsevier Science Publishers B. V., 1990)
The ribosomal protein S4 from Escherichia coli is essential for initiation of assembly of 30S ribosomal subunits. We have undertaken the identification of specific features required in the 16S rRNA for S4 recognition by ...
The structure of the 80S ribosome from Trypanosoma cruzi reveals unique rRNA components
(National Academy of Sciences, 2005-07)
We present analysis, by cryo-electron microscopy and single-particle reconstruction, of the structure of the 80S ribosome from Trypanosoma cruzi, the kinetoplastid protozoan pathogen that causes Chagas disease. The density ...
Convergent evolution led ribosome inactivating proteins to interact with ribosomal stalk
(Elsevier, 2012-01)
Ribosome-inactivating proteins (RIPs) inhibit protein synthesis by depurinating an adenine on the sarcin–ricin loop (SRL) of the large subunit ribosomal RNA. Several RIPs interact with the C-terminal end of ribosomal stalk ...
RNA-DNA differences in human mitochondria restore ancestral form of 16S ribosomal RNA
(2013)
RNA transcripts are generally identical to the underlying DNA sequences. Nevertheless, RNA-DNA differences (RDDs) were found in the nuclear human genome and in plants and animals but not in human mitochondria. Here, by ...
Nop53p interacts with 5.8S rRNA co-transcriptionally, and regulates processing of pre-rRNA by the exosome
(WILEY-BLACKWELL, 2008)
In eukaryotes, pre-rRNA processing depends on a large number of nonribosomal trans-acting factors that form intriguingly organized complexes. One of the early stages of pre-rRNA processing includes formation of the two ...
Ribosomal rna heterogeneity and identification of toxic dinoflagellate cultures by heteroduplex mobility assay
(WILEY-BLACKWELL, 1999)
The heteroduplex mobility assay (NMA) reveals sequence dissimilarity between DNA by measuring the retarded migration of the hybrid or heteroduplex using polyacrylamide gel electrophoresis, Heterogeneity in some cultures ...