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Peripheral kappa and delta opioid receptors are involved in the antinociceptive effect of crotalphine in a rat model of cancer pain
(2013-06-17)
Cancer pain is an important clinical problem and may not respond satisfactorily to the current analgesic therapy. We have characterized a novel and potent analgesic peptide, crotalphine, from the venom of the South American ...
Peripheral kappa and delta opioid receptors are involved in the antinociceptive effect of crotalphine in a rat model of cancer pain
(2013-06-17)
Cancer pain is an important clinical problem and may not respond satisfactorily to the current analgesic therapy. We have characterized a novel and potent analgesic peptide, crotalphine, from the venom of the South American ...
Cross-tolerance to acute administration of mu and kappa opioid agonists at the spinal cord level in the rat
(1996)
Development of tolerance and cross-tolerance after acute administration of the μ agonist morphine and the K agonist U-50,488H was assessed in rats, through recording of a C-fiber-evoked spinal nociceptive reflex. Rats ...
A structure-affinity study of the opioid binding of some 3-substituted morphinans
(SOCIEDAD CHILENA DE QUIMICA, 2004-12)
A ZINDO/1 quantum-chemical structure-affinity relationship study is presented for the interaction of a group of 3-substituted morphinans with mu, delta and kappa opioid receptors. From this and previous work it is concluded ...
A STRUCTURE-AFFINITY STUDY OF THE OPIOID BINDING OF SOME 3-SUBSTITUTED MORPHINANS
(Sociedad Chilena de Química, 2004)
Modelo de aprendizaje automático para predecir el riesgo de evento adverso en analgésicos opioides aplicando datos de secuenciación de última generación (NGS) en una población de pacientes colombianos
(Universidad Nacional de ColombiaBogotá - Ingeniería - Maestría en BioinformáticaFacultad de IngenieríaBogotá, ColombiaUniversidad Nacional de Colombia - Sede Bogotá, 2022-11-02)
OBJETIVO: Desarrollar un modelo basado en aprendizaje automático para la predicción del riesgo de evento adverso, a partir del genotipo en farmacogenes asociados con la farmacocinética y farmacodinámica de analgésicos ...