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Hidden Structural Codes in Protein Intrinsic Disorder
(American Chemical Society, 2017-10)
Intrinsic disorder is a major structural category in biology, accounting for more than 30% of coding regions across the domains of life, yet consists of conformational ensembles in equilibrium, a major challenge in protein ...
MobiDB 3.0: More annotations for intrinsic disorder, conformational diversity and interactions in proteins
(Oxford University Press, 2018-01)
The MobiDB (URL: mobidb.bio.unipd.it) database of protein disorder and mobility annotations has been significantly updated and upgraded since its last major renewal in 2014. Several curated datasets for intrinsic disorder ...
Intrinsic disorder perspective of an interplay between the renin- angiotensin-aldosterone system and SARS-CoV-2
The novel severe acute respiratory syndrome (SARS) coronavirus SARS-CoV-2 walks the planet
causing the rapid spread of the CoV disease 2019 (COVID-19) that has especially deleterious
consequences for the patients with ...
Minute time scale prolyl isomerization governs antibody recognition of an intrinsically disordered immunodominant epitope
(American Society For Biochemistry And Molecular Biology, 2013-03)
Conformational rearrangements in antibody·antigen recognition are essential events where kinetic discrimination of isomers expands the universe of combinations. We investigated the interaction mechanism of a monoclonal ...
The emergence of new catalytic abilities in an endoxylanase from family GH10 by removing an intrinsically disordered region
(MDPI, 2022)
Endoxylanases belonging to family 10 of the glycoside hydrolases (GH10) are versatile in the use of different substrates. Thus, an understanding of the molecular mechanisms underlying substrate specificities could be very ...
Chasing coevolutionary signals in intrinsically disordered proteins complexes
(Nature, 2020-10)
Intrinsically disordered proteins/regions (IDPs/IDRs) are crucial components of the cell, they are highly abundant and participate ubiquitously in a wide range of biological functions, such as regulatory processes and cell ...
Intrinsic disorder is a key characteristic in partners that bind 14-3-3 proteins
(Wiley-liss, Div John Wiley & Sons Inc, 2006-04)
Proteins named 14-3-3 can bind more than 200 different proteins, mostly (but not exclusively) when they are at a phosphorylated state. These partner proteins are involved in different cellular processes, such as cell ...
Phosphorylation regulates the bound structure of an intrinsically disordered protein: The p53-TAZ2 case
(Public Library of Science, 2016-01-07)
Disordered regions and Intrinsically Disordered Proteins (IDPs) are involved in critical cellular processes and may acquire a stable three-dimensional structure only upon binding to their partners. IDPs may follow a ...
The N-terminal module of HPV16 E7 is an intrinsically disordered domain that confers conformational and recognition plasticity to the oncoprotein
(American Chemical Society, 2007-08)
The HPV16 E7 oncoprotein is an extended dimer, with a stable and cooperative fold, but that displays properties of "natively unfolded" proteins. Two regions of conserved sequence are found in E7 proteins, where the N-terminus ...
Intrinsically Disordered Protein Ensembles Shape Evolutionary Rates Revealing Conformational Patterns
(Academic Press Ltd - Elsevier Science Ltd, 2021-02-05)
Intrinsically disordered proteins (IDPs) lack stable tertiary structure under physiological conditions. The unique composition and complex dynamical behaviour of IDPs make them a challenge for structural biology and molecular ...