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Induced sputum is safe and well-tolerated for TB diagnosis in a resource-poor primary healthcare setting
(American Society of Tropical Medicine and Hygiene, 2015)
Improved tuberculosis (TB) diagnostics are required. Induced sputum sampling is superior to spontaneous sputum analysis for diagnosis of pulmonary TB. Therefore, we examined the applicability of induced sputum in primary ...
Relationship between induced sputum cytology and inflammatory status with lung structural and functional abnormalities in asbestosis
(WILEY-LISS, 2008)
Background Asbestosis is associated with lung cellular and immunological abnormalities. Induced sputum cytology and local and systemic markers of inflammation may be helpful to characterize disease status and progression ...
Nasal eosinophilia: an indicator of eosinophilic inflammation in asthma
(WILEY-BLACKWELL, 2010)
Background It is noteworthy that there is a clear clinical, epidemiological and pathophysiological association between upper and lower airway inflammation in rhinitis and asthma. Objective The aim of this study was to ...
Effects of active smoking on airway and systemic inflammation profiles in patients with chronic obstructive pulmonary disease
(2013-06-01)
Background: The markers that characterize local and systemic inflammation in chronic obstructive pulmonary disease (COPD) remain unclear, as do their correlations with smoking status and presence of disease. The aim of ...
Induced Sputum MMP-1, -3 & -8 Concentrations during Treatment of Tuberculosis
(Public Library of Science, 2013)
Introduction: Tuberculosis (TB) destroys lung tissues and this immunopathology is mediated in part by Matrix Metalloproteinases (MMPs). There are no data on the relationship between local tissue MMPs concentrations, ...
Analysis of aberrant methylation on promoter sequences of tumor suppressor genes and total DNA in sputum samples: A promising tool for early detection of COPD and lung cancer in smokers
(2012)
Background: Chronic obstructive pulmonary disease (COPD) is a disorder associated to cigarette smoke and lung cancer (LC). Since epigenetic changes in oncogenes and tumor suppressor genes (TSGs) are clearly important in ...
The spectrum of tuberculosis described as differential DNA methylation patterns in alveolar macrophages and alveolar T cells
(BioMed Central, 2022)
Background: Host innate immune cells have been identified as key players in the early eradication of Mycobacterium tuberculosis and in the maintenance of an anti-mycobacterial immune memory, which we and others have shown ...
Clinical characteristics and possible phenotypes of an adult severe asthma population
(W B SAUNDERS CO LTDLONDON, 2013-08-02)
Background: Currently, there are no studies of well-characterized severe asthmatics in Brazil. We aimed to study a population of severe treated asthmatics still uncontrolled to characterize them and define possible phenotypes. ...