Buscar
Mostrando ítems 1-10 de 158
Mapping of B cell epitopes in an immunodominant antigen of Trypanosoma cruzi using fusions to the Escherichia coli LamB protein
(Elsevier B.V., 1998-07-01)
The JL8 protein antigen from Trypanosoma cii , a dominant immunogen in man, has been characterized as containing tandem amino acid repeats. Here, we describe the use of the LamB protein of Escherichia coli as a carl icr ...
A Systematic, Unbiased Mapping of CD8+ and CD4+ T Cell Epitopes in Yellow Fever Vaccinees
(Frontiers Media S.A., 2020-08)
Examining CD8+ and CD4+ T cell responses after primary Yellow Fever vaccination in a cohort of 210 volunteers, we have identified and tetramer-validated 92 CD8+ and 50 CD4+ T cell epitopes, many inducing strong and prevalent ...
Identification of immunodominant proteins from the Viannia and Leishmania subgenera for the composition of a pan vaccine specific for leishmaniasis
(Fiocruz/Instituto de Tecnologia em Imunobiológicos, 2022)
Infection with Trypanosoma cruzi restricts the repertoire of parasite-specific CD8(+) T cells leading to immunodominance
(American Association of Immunologists, 2023)
Mapping of B-cell epitopes in a antigen expressed Trypanosoma cruzi immunodominant in natural infections
(Amer Soc Microbiology, 2005-02-01)
Tc40 is an immunodominant antigen present in natural Trypanosoma cruzi infections. This immunogen was thoroughly mapped by using overlapping amino acid sequences identified by gene cloning and chemical peptide synthesis. ...
Identification of immunodominant epitopes of Schistosoma mansoni vaccine candidate antigens using human T cells
(Fundação Oswaldo Cruz, 2014)
PREDIVAC : CD4+ T-cell epitope prediction for vaccine design that covers 95% of HLA class II DR protein diversity
(2013-02-14)
Background: CD4+ T-cell epitopes play a crucial role in eliciting vigorous protective immune responses during peptide (epitope)-based vaccination. The prediction of these epitopes focuses on the peptide binding process by ...
B-Cell Epitopes in the Immunodominant p34 Antigen of Mycobacterium avium ssp. paratuberculosis Recognized by Antibodies from Infected Cattle
(Wiley Blackwell Publishing, Inc, 2003-11)
Mycobacterium avium ssp. paratuberculosis (M. paratuberculosis) causes Johne's disease, a chronic and fatal enteritis in ruminants. In the last stage of the disease, antibody titres rise and levels of interferon-γ decrease, ...
SARS-CoV-2 genome-wide T cell epitope mapping reveals immunodominance and substantial CD8+ T cell activation in COVID-19 patients
(American Association for the Advancement of Science, 2021-04)
T cells are important for effective viral clearance, elimination of virus-infected cells and long-term disease protection. To examine the full-spectrum of CD8+ T cell immunity in COVID-19, we experimentally evaluated 3141 ...