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Enhanced immunization techniques to obtain highly specific monoclonal antibodies
(2018-01-02)
Despite fast advances in genomics and proteomics, monoclonal antibodies (mAbs) are still a valuable tool for areas such as the evolution of basic research in stem cells and cancer, for immunophenotyping cell populations, ...
Age-related changes in ocular mucosal tolerance: Lessons learned from gut and respiratory tract immunity
(Wiley Blackwell Publishing, Inc, 2021-04)
The ocular surface is the part of the visual system directly exposed to the environment, and it comprises the cornea, the first refractive tissue layer and its surrounding structures. The ocular surface has evolved to keep ...
Multiple Tolerization Reduces Antibody Binding Against Tolerogen Cells: Implications for the Production of Monoclonal Antibodies
(2018-04-01)
We report an immunization technique that can update the production of monoclonal antibodies (mAbs): the multiple tolerization subtractive immunization (MTSI). A total of 10 BALB/C mice were used. Animals in group 1 received ...
Turning 'sweet' on immunity: galectin–glycan interactions in immune tolerance and inflammation
(Macmillan Publisher Limited, 2009-05)
The function of deciphering the biological information encoded by the glycome, which is the entire repertoire of complex sugar structures expressed by cells and tissues, is assigned in part to endogenous glycan-binding ...
Microorganisms in the female genital tract during pregnancy: tolerance versus pathogenesis
(Wiley-Blackwell, 2015-05-01)
Microorganisms in the pregnant female genital tract are not always associated with pathology. The factors that influence the maternal response to microorganisms remain ill defined. We review the state of knowledge of ...
Papel dos eventos inflamatórios induzidos pela imunização na manutenção de tolerância oral
(Universidade Federal de Minas GeraisUFMG, 2008-02-19)
Oral tolerance is a complex phenomenon defined as a state of systemichyporesponsiveness to an antigen that has been previously administered by the oral route. Many factors affect oral tolerance induction, some of them ...
Mucosal immune tolerance at the ocular surface in health and disease
(Wiley Blackwell Publishing, Inc, 2017-04)
The ocular surface is constantly exposed to environmental irritants, allergens and pathogens, against which it can mount a prompt immune response to preserve its integrity. But to avoid unnecessary inflammation, the ocular ...
Immune cells and oxidative stress in the endotoxin tolerance mouse model
(Associação Brasileira de Divulgação Científica, 2010)
Sepsis is a systemic inflammatory response that can lead to tissue damage and death. In order to increase our understanding of sepsis, experimental models are needed that produce relevant immune and inflammatory responses ...